Risk stratification and pattern of cardiotoxicity in pediatric ewing sarcoma
Joint Authors
Salah, Zaynab
Sulayman, Ranin
Musa, Imad
Izzat, Samirah
Zamzam, Manal
Kamil, Ahmad
Atiyyah, Iman A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 29, Issue 1 (31 Mar. 2017), pp.53-56, 4 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2017-03-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Introduction: Anthracycline chemotherapy contributes to improved outcomes in Ewing sarcoma; however, the most feared complication is cardiotoxicity.
Echocardiograms were routinely used to monitor cardiac function after anthracycline treatment.
Nevertheless, indices chosen to assess cardiac toxicity vary significantly among different centers, and no uniform protocol has been accepted as ideal.
Methods: This retrospective study included children with Ewing sarcoma treated at Children’s Cancer Hospital Egypt over 4 years.
All echocardiograms and related clinical assessments were reviewed.
Results: In total, 149 patients (median age 11 years; range 1–18 years) were included.
Although all patients had a reduced ejection fraction compared with their baseline echocardiogram, only 39 patients developed cardiotoxicity (26%): 43% acute-onset, 36% chronic early-onset, and 21% chronic late-onset.
There were no statistically significant association between the frequency of myocardial dysfunction and risk factors, including age, sex, follow-up duration, cumulative doxorubicin dose, and mediastinal irradiation.
Over one-third (39%) of the patients with cardiac toxicity regained normal cardiac parameters, whereas seven patients died of acute cardiac toxicity.
Conclusion: The routine use of echocardiography to screen for anthracycline-induced cardiac toxicity before and during chemotherapy identified myocardial dysfunction.
Early medical intervention can improve cardiac parameters.
Improved screening techniques with better sensitivity and predictability are needed.
American Psychological Association (APA)
Musa, Imad& Zamzam, Manal& Kamil, Ahmad& Salah, Zaynab& Atiyyah, Iman A.& Sulayman, Ranin…[et al.]. 2017. Risk stratification and pattern of cardiotoxicity in pediatric ewing sarcoma. Journal of the Egyptian National Cancer Institute،Vol. 29, no. 1, pp.53-56.
https://search.emarefa.net/detail/BIM-733778
Modern Language Association (MLA)
Musa, Imad…[et al.]. Risk stratification and pattern of cardiotoxicity in pediatric ewing sarcoma. Journal of the Egyptian National Cancer Institute Vol. 29, no. 1 (Mar. 2017), pp.53-56.
https://search.emarefa.net/detail/BIM-733778
American Medical Association (AMA)
Musa, Imad& Zamzam, Manal& Kamil, Ahmad& Salah, Zaynab& Atiyyah, Iman A.& Sulayman, Ranin…[et al.]. Risk stratification and pattern of cardiotoxicity in pediatric ewing sarcoma. Journal of the Egyptian National Cancer Institute. 2017. Vol. 29, no. 1, pp.53-56.
https://search.emarefa.net/detail/BIM-733778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 56
Record ID
BIM-733778