Prevalence of glucose-6-phosphate dehydrogenase deficiency in India : an updated meta-analysis
Joint Authors
Yadav, Upendra
Rai, Vandana
Kumar, Pradeep
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 17, Issue 3 (31 Jul. 2016), pp.295-302, 8 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Glucose-6-phosphate dehydrogenase (G6PD) is a house keeping enzyme which catalyzes the first step in the hexose monophosphate pathway of glucose metabolism.
G6PD deficiency is the commonest hemolytic X-linked genetic disease, which affects approximately 400 million people worldwide.
The prevalence rate of G6PD deficiency varies worldwide with a higher prevalence in malarial endemic population.
In India several studies were published and reported with varying incidences of this disease in different populations.
Objective: The aim of the present study was to assess the overall frequency of G6PD deficiency in the Indian population using meta-analysis.
Methods: PubMed, Science Direct, Google Scholar and Springer Link databases were searched for studies that investigated G6PD deficiency in Indian population.
If any author studied different sub-populations we treated the study as an independent study.
Results: A total of 72 studies with a total sample size of 38,565 and 2,623 G6PD deficient subjects were included in the present meta-analysis.
Meta-analysis was performed in both fixed and random effect models.
Meta-analysis with random model showed an overall prevalence proportion as 0.085 (95% CI = 0.070–0.103; p= 0.000; tau =0.826; I2 = 0.486; Cochran Q =0.999).
Conclusion: In conclusion the present meta-analysis confirms the overall magnitude of the frequency of G6PD deficiency (8.5%) in the Indian population
American Psychological Association (APA)
Kumar, Pradeep& Yadav, Upendra& Rai, Vandana. 2016. Prevalence of glucose-6-phosphate dehydrogenase deficiency in India : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 3, pp.295-302.
https://search.emarefa.net/detail/BIM-734014
Modern Language Association (MLA)
Yadav, Upendra…[et al.]. Prevalence of glucose-6-phosphate dehydrogenase deficiency in India : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 3 (Jul. 2016), pp.295-302.
https://search.emarefa.net/detail/BIM-734014
American Medical Association (AMA)
Kumar, Pradeep& Yadav, Upendra& Rai, Vandana. Prevalence of glucose-6-phosphate dehydrogenase deficiency in India : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 3, pp.295-302.
https://search.emarefa.net/detail/BIM-734014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 301-302
Record ID
BIM-734014