Hepatic and renal toxicity of dichlorvos in male domestic rabbits
Other Title(s)
سمية مبيد ديكلورفوس على كبد و كلية ذكور الأرانب المنزلية
Dissertant
Thesis advisor
Abd Rabbih, Abd al-Fattah Nazmi Hasan
Yasin, Majid M.
University
Islamic University
Faculty
Faculty of Science
Department
Department of Biological Science
University Country
Palestine (Gaza Strip)
Degree
Master
Degree Date
2016
English Abstract
Objective: The present study is aimed to assess hepatic and renal toxicity of dichlorvos in male domestic rabbits Materials and Methods: The oral LD50 of dichlorvos in male domestic rabbit was calculated from linear regression and found to be 11.6 mg/kg body weight.
A daily dose of 1/10 LD50 of dichlorvos (1.2 mg/kg body weight) were given to the animals under experiment for six weeks.
Control animals were given distilled water.
Blood samples were collected weekly and analyzed.
Results: The overall mortality rate was 6.3% in dichlorvos-treated rabbits compared to no mortalities in controls.
Clinical signs included diarrhea, reduced food intake, weakness, disorientation, drowsiness and mild tremors.
The growth rate was significantly decreased in dichlorvos-intoxicated rabbits.
Serum glucose was significantly increased in response to dichlorvos administration recording a maximum percentage difference of 26.7% in the 4th week of the experiment.
The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly higher in dichlorvos-fed rabbits compared to controls, registering maximum percentage differences of 29.4% and 38.6%, respectively during the 5th week of the experiment.
Alkaline phosphatase (ALP) and gamma glutamyl transferase (-GT) were also significantly increased recording maximum percentages of 27.8% and 38.1 in the 4th and 6th weeks of the experiment, respectively.
In contrast, serum cholinesterase (ChE) was progressively decreased recording a maximum percentage difference of 72.6% at the end of the experiment.
Serum bilirubin was gradually increased to record a maximum percentage difference of 23.3% in the 5th week.
Serum urea and creatinine concentrations were significantly elevated in response to dichlorvos intake displaying maximum percentage differences of 35.4% and 29.6% during the 6th and 5th weeks of the experiment, respectively.
Serum total protein, albumin and globulin were significantly decreased upon dichlorvos intoxication exhibiting percentage differences of 31.2, 30.2 and 31.4% at 4th week of the experiment.
Serum calcium was significantly increased in dichlorvos-treated rabbits with a maximum percentage difference of 24.3% at the 4th week whereas phosphorus was significantly decreased with a maximum percentage difference of 28.6% at the 6th week of the experiment.
Conclusions: Dichlorvos caused hepatic and renal toxicity in rabbit through alterations of liver and kidney functions.
Main Subjects
No. of Pages
71
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Materials and methods.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion.
References.
American Psychological Association (APA)
al-Malihi, Bassam Khalil. (2016). Hepatic and renal toxicity of dichlorvos in male domestic rabbits. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-735245
Modern Language Association (MLA)
al-Malihi, Bassam Khalil. Hepatic and renal toxicity of dichlorvos in male domestic rabbits. (Master's theses Theses and Dissertations Master). Islamic University. (2016).
https://search.emarefa.net/detail/BIM-735245
American Medical Association (AMA)
al-Malihi, Bassam Khalil. (2016). Hepatic and renal toxicity of dichlorvos in male domestic rabbits. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-735245
Language
English
Data Type
Arab Theses
Record ID
BIM-735245
