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The transcription factor Zfhx1a is expressed in the embryonic chick spinal cord glial cells
Other Title(s)
التعبير عن عامل الانتساخ Zfhx1a في الخلايا الدبقية للنخاع الشوكي في جنين الدجاج
Author
Source
Damascus University Journal for the Basic Sciences
Issue
Vol. 30, Issue 1 (30 Jun. 2014), pp.65-76, 12 p.
Publisher
Publication Date
2014-06-30
Country of Publication
Syria
No. of Pages
12
Main Subjects
Abstract EN
In Drosophila, the zing-finger homeodomain transcription factors zfh are expressed in many tissues including nervous system.
Two vertebrate homologues, Zfhx1a and Zfhx1b have been characterized.
These genes have been implicated in epithelial-mesenchymal transitions (EMT) in normal development as well as in tumorigenesis.
However, the expression and the role of these genes in developing vertebrates nervous system is unknown.
Here we describe the expression patterns of Zfhx1a in the embryonic chick spinal cord as determined by immunohistochemistry from days 1.5 (E1.5) to 14 (E14) of incubation.
We have shown that Zfhx1a is feebly expressed in the neural progenitors in the ventricular zone (VZ) at around day 4.
This expression becomes strong at E6.
Starting from E7, we have observed that ZFHx1a+ cells stream away from the VZ and migrate to the mantle layer of the spinal cord.
Double immunostaining shows no overlap between Zfhx1a and pan-neuronal markers (NeuN and HuC/D).
However, there was extensive overlap between Zfhx1a and either oligodendrocyte markers (Olig2 and Nkx2.2) or astrocyte marker (GFAP).
We conclude that Zfhx1a is expressed in glial cells in the chick embryo spinal cord.
American Psychological Association (APA)
Sukariyah, Shadi. 2014. The transcription factor Zfhx1a is expressed in the embryonic chick spinal cord glial cells. Damascus University Journal for the Basic Sciences،Vol. 30, no. 1, pp.65-76.
https://search.emarefa.net/detail/BIM-740624
Modern Language Association (MLA)
Sukariyah, Shadi. The transcription factor Zfhx1a is expressed in the embryonic chick spinal cord glial cells. Damascus University Journal for the Basic Sciences Vol. 30, no. 1 (2014), pp.65-76.
https://search.emarefa.net/detail/BIM-740624
American Medical Association (AMA)
Sukariyah, Shadi. The transcription factor Zfhx1a is expressed in the embryonic chick spinal cord glial cells. Damascus University Journal for the Basic Sciences. 2014. Vol. 30, no. 1, pp.65-76.
https://search.emarefa.net/detail/BIM-740624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 74-76
Record ID
BIM-740624