The anti-hyperglycemic effect of Solenostemma argel compared with Glibenclamide
Other Title(s)
التأثير الخافض للسكر لنبات الحرجل بالمقارنة مع عقار Glibenclamide في الجرذان المصابة بذاء السكري
Joint Authors
Taha, Layla al-Tayyib
Bakhit, Siham Muhammad Ahmad
Uro, Abu Bakr O.
al-Saidi, Jabbar Abbas Ahmad
Source
al-Qadisiyah Journal of Veterinary Medicine Sciences
Issue
Vol. 13, Issue 2 (31 Dec. 2014), pp.113-117, 5 p.
Publisher
al-Qadisiyah University College of Veterinary Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
The current study aimed to compare the anti-hyperglycemic effect of Solenostemma argel, which widely used for the treatment of diabetes mellitus in Sudan, with the antidiabetic drug (Glibenclamide).
Twenty four albino rats were used in this experiment.
Rats were assigned to 4 groups (N=6).
All groups were fasted for 18 hrs.
Group (1) was administered with glibenclamide (10 mg/kg b.w.) and served as control, groups (2, 3, and) were orally administered with aqueous extract of Solenostemma argel leaves and bark (200, 400, and 800 mg/kg b.w.), respectively, after loading with 5% glucose (2 mg/kg b.w).
Blood samples were obtained to assess blood glucose, lipid profile and α-amylase concentrations.
Sub chronic toxicity of Solenostemma argel has been evaluated which clearly demonstrated the non-toxic nature and safety profile.
Obtained results indicated that Solenostemma argel aqueous extract significantly decreased blood glucose level in treated group received 800 mg/kg b.w.
compared with glibenclamide treated group.
At the dose of 200 mg/kg b.w.
of Solenostemma argel aqueous extract, the activity of α-amylase decreased in comparison with that treated with glibenclamide and registered low concentrations of cholesterol and HDL as well.
In conclusion, both blood glucose level and α-amylase activity can be ameliorated in diabetic rats by administration of Solenostemma argel aqueous extract.
However, in prospective study more investigation has should to be carried out to explain the mechanism of Solenostemma argel in hypoglycemic animals.
American Psychological Association (APA)
Taha, Layla al-Tayyib& Bakhit, Siham Muhammad Ahmad& al-Saidi, Jabbar Abbas Ahmad& Uro, Abu Bakr O.. 2014. The anti-hyperglycemic effect of Solenostemma argel compared with Glibenclamide. al-Qadisiyah Journal of Veterinary Medicine Sciences،Vol. 13, no. 2, pp.113-117.
https://search.emarefa.net/detail/BIM-743411
Modern Language Association (MLA)
Taha, Layla al-Tayyib…[et al.]. The anti-hyperglycemic effect of Solenostemma argel compared with Glibenclamide. al-Qadisiyah Journal of Veterinary Medicine Sciences Vol. 13, no. 2 (2014), pp.113-117.
https://search.emarefa.net/detail/BIM-743411
American Medical Association (AMA)
Taha, Layla al-Tayyib& Bakhit, Siham Muhammad Ahmad& al-Saidi, Jabbar Abbas Ahmad& Uro, Abu Bakr O.. The anti-hyperglycemic effect of Solenostemma argel compared with Glibenclamide. al-Qadisiyah Journal of Veterinary Medicine Sciences. 2014. Vol. 13, no. 2, pp.113-117.
https://search.emarefa.net/detail/BIM-743411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 117
Record ID
BIM-743411