The effect of aqueous extract of green tea (Camellia sinensis)‎ on liver enzymes of experimentally induced diabetes mellitus in mature female rabbits

Abstract EN

This study was carried out to find the effect of aqueous extract of green tea on liver enzymes in alloxan induced diabetic adult female rabbits.

Thirty five female rabbits weighted 1-1.5 kg were divided into five groups and treated for 8 weeks as follows.

Group 1: intact rabbits were drenched with 2ml of drinking water for 8 weeks as control group.

Group 2 (T1): diabetic rabbits were drenched with 2ml of drinking water as placebo.

Group 3 (T2): Diabetic rabbits were drenched with single daily dose of green tea extract (200mg/kg body weight).

Group 4 (T3): Diabetic rabbits were daily injected with insulin (3 I.U subcutaneous) for 8 weeks.

Group 5 (T4): intact rabbits were drenched with single daily dose of green tea (200mg/kg body weight).

At the end of experiment the blood samples were taken by cardiac puncture, the blood serum was separated to measure liver enzymes.

The results revealed that significantly decreased (p< 0.05) was observed in aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) levels in all treated groups, while increased significantly in diabetic group.

This study concluded that aqueous extract of green tea can act as hepatoprotective agent.