Hypoglycemic and hypolipidimic effect of Naringin in diabetic male rats

Abstract EN

The current study aimed to determine the potency of aqueous extract of grape fruit (Naringin) in lowering blood glucose and lipid profile in streptozotocin induced diabetic male rats (by single injection of Streptozotocin at the dose of 60 mg/kg of the body weight).

Naringin was extracted from grapefruit albedo (white inner Pell) by using aqueous hydrolysis, then it was identified on Thin Layer Chromatography (TLC).The results of thin layer chromatography have showed that Rf values was 0.75 in aqueous extract compared with Rf standard naringin (0.76).Twenty four adult male rats were randomly assigned to three equal groups treated for 30 days as follows: Intact control (C) , Diabetic Control (D.M.), treated diabetic rats (T) received (80mg/kg B.W.) of flavonoids (naringin).

Blood sample were obtained befor and after 10,20 and 30 days from treatment.

The results showed significant decrease in body weight , blood glucose , cholesterol, and triglyceride in T group.

These results showed that naringin has potential hypoglycemic and hypolipidemic effect in streptozotocin induced diabetic rats.