Acute and chronic pathological effects with biochemical alteration of thyroid gland induced by NaF in Wistar rats
Other Title(s)
التأثيرات المرضية الحادة و الزمنة و التغيرات الكيموحيوية للغدة الدرقية الناجمة عي التسمم بولح فلوريد الصوديوم في الجرذان البيضاء
Author
Source
al-Qadisiyah Journal of Veterinary Medicine Sciences
Issue
Vol. 13, Issue 1 (30 Jun. 2014), pp.66-74, 9 p.
Publisher
al-Qadisiyah University College of Veterinary Medicine
Publication Date
2014-06-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Thirty Wistar albino rats of both sex, 1-1.25 months old (average body weight 250 – 300gm) were used.
Animals were randomly divided into three groups.
1st group (acute group) n=10 given 0.5 ml.
contain 500 mg/kg/body weight NaF, as single toxic dose via stomach tube.
2nd group (chronic group) n=10 given 0.5 ml.
contain 150 mg/kg/body weight NaF via stomach tube daily for 60 days.
3rd group (control group) n=10 given 0.5 ml.
physiological saline via stomach tube.
Clinical signs were reported during the course of the study, and then sacrificed after 3 and 7 days in 1st group, and 30 and 60 days in 2nd group, then post mortem examination was done, and any gross lesions were reported.
Blood collected was done for biochemical examination (T3, T4, and TSH.) using special biochemical kits.
Pieces of thyroid were taken, fixed in 10% formalin for 72 hours, and then all the specimens were processed and the histopathological changes were observed under light microscope.
The pathological results showed hemorrhage appear in capsular region of thyroid gland with vacuolation in cytoplasm of cell of colloid with neutrophils infiltration in lumen, as well as edema with fume cytoplasm and marked vacuolation of cytoplasm of colloid cell, also granulomatous lesion seated in gland parenchyma.
That causes alteration of biochemical test T3, T4 and TSH in acute and chronic toxic doses.
American Psychological Association (APA)
Jawad, Basim Muhammad. 2014. Acute and chronic pathological effects with biochemical alteration of thyroid gland induced by NaF in Wistar rats. al-Qadisiyah Journal of Veterinary Medicine Sciences،Vol. 13, no. 1, pp.66-74.
https://search.emarefa.net/detail/BIM-743499
Modern Language Association (MLA)
Jawad, Basim Muhammad. Acute and chronic pathological effects with biochemical alteration of thyroid gland induced by NaF in Wistar rats. al-Qadisiyah Journal of Veterinary Medicine Sciences Vol. 13, no. 1 (2014), pp.66-74.
https://search.emarefa.net/detail/BIM-743499
American Medical Association (AMA)
Jawad, Basim Muhammad. Acute and chronic pathological effects with biochemical alteration of thyroid gland induced by NaF in Wistar rats. al-Qadisiyah Journal of Veterinary Medicine Sciences. 2014. Vol. 13, no. 1, pp.66-74.
https://search.emarefa.net/detail/BIM-743499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 74
Record ID
BIM-743499