Effect of ivermectin on semen parameters and levels of alanine aminotransferase (ALT)‎ and aspartate aminotransferase (AST)‎ enzymes in seminal plasma of Iraqi Awassi rams

Abstract EN

The objective of this study was to evaluation the effect of Ivermectin on semen quality and estimation of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in seminal plasma.

Six mature Awassi rams aged 2-3 years and weighing 38-42 Kg were used in this study.

Semen collection was done weekly for five weeks from the same ram.

The first two collection was considers as training for the animal and discarded, the second two collection were considers for control group.

After administration of the drug (Ivermectin), semen samples were collected from the Awassi ram 1, 7,14 days.

The parameter studies were included semen volume, percentage motility of sperm, sperm concentration, live sperm, and morphology percentage.

Samples of seminal plasma were analyzed for the estimation of alanine aminotransferase (ALT), aspartate aminotransferase (AST).

Results of this study indicate that Ivermectin leads to significant (P<0.05) decreased in semen parameters after first semen collection.

Reaction time significantly higher (P<0.05) in the treated group after 1 days of injection.

Alanine aminotransferase ALT, Aspartate aminotransferase AST show no significant differences in activities in seminal plasma during study.

In conclusion: it is preferable to use the animals for the purpose of reproduction only after at least 7 days after Ivermectin injection due to it harmful effect on semen quality.