دراسة جرثومية عشوائية ثنائية التعمية للأزيترومايسين الجهازي كمعالجة داعمة للتقليح و تسوية الجذور لالتهاب الأنسجة حول السنية الاجتياحي

Abstract EN

Background & Objective: This study is carried out by using PCR technique to assess the efficacy of systemic azithromycin as a supplement to scaling and root planning (SRP) in the treatment of aggressive periodontitis (AgP) in three months follow up on the periodontal pathogens compared with a control group.

Materials&Methods: 26 patients, 14–28 years old (mean 21y) were examined with aggressive periodontitis in the Department of Periodontology in Damascus university, the study was double-blind.

All subjects received scaling and root planning in one session, and randomized into 2 groups, the test group(13 patients) was treated with supplementary azithromycin 500 mg tablets once daily for 3 days, the control(13 patients) group was administered placebo tablets (Al Fares company-Syria).

And subgingival plaque was collected from the deepest 5 pockets using paper strips (N=260) before treatment and 3 months postoperatively.

The plaque samples were used to assess presence of 11 periodontal bacteria using the micro-IDent®plus Test (Hain Lifescience, Nehren, Germany).

Mann-Whitney and Wilcoxon were used to compare group means.

Results: The periodontal pathogens in the test group before treatment was between (12.5 ,17.08), and in the placebo group was (14.5 ,9.92), and had a significant decrease after 3 months (p<0.05) in the number of sites with detectable Aa, Pg, Tf, Fn, Td, and Cr.

An increase in detectable bacteria was for all bacteria and significantly in (P=0.04) Pm, (P=0.02) En in the control group.

Conclusion: The use of azithromycin as a supplement to scaling and root planning in treatment of aggressive periodontitis significantly reduces the number of sites with detectable periodontal pathogens