دراسة الفعالية المعالجة و الواقية لخلاصة ثمار نبات الإكباليوم (قثاء الحمار)‎ Ecballium elaterium من الفصيلة القرعية Cucurbitacinaceae من السمية الكبدية

Abstract EN

Background & Objective: Evaluation Ecballium elaterium fruits juice activity on hepatic cell level using experimental animals in two towards :hepatotoxicity treatment and prevention induced by Carbon tetrachloride (CCL4 ) .

Material& methods: This effect was studied on Wister rats in groups: (Normal group, group given single dose of CCL4(1ml/kg ), treated group given dose of Ecballium elaterium fruit juice (0.5ml ) for three days consecutive after the injury inducing, prevention group given dose of Ecballium elaterium fruit juice ( 0.1 ml )for three days consecutive before the injury inducing, group given dose of juice equal to prevention dose(0.1ml/kg) for three days consecutive whithout inducing injury, treated group given dose ofreference drug (1.35 mg/kg)for three days consecutive after the injury inducing, The prevention group given dose of reference drug (1.35 mg/kg)for three days consecutive before the injury inducing.

Result :Results showed clear increase in serum values of serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase(SGOT), with high degrees of hepaticsteatosis, necrosis and inflammation in illness group comparative with normal one, also showed clear decrease in values SGPT and SGOT for treatment and prevention plant juice groups comparative with illness one and which make sure by results of histology study in decrease degrees of steatosis, necrosis and inflammation of the liver.

Conclusion: The study comfier activity of plant juice in the treatment and prevention from hepatotoxicity induced by CCL4