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The synergistic effect of zinc, coumestrol, genestein and daidzein on proinflammatory cytokines production and receptor activator of NFκB ligand expression that implicates in bone resorption
Other Title(s)
التأثير التازري للزنك مع الجنستين، الكومسترول و الدايدزين في إنتاج الوسائط الخلوية البادئة للالتهاب و تعبير المستقبل المنشط لرابط العامل النووي كابا المرتبطين بتنخر العظام
Author
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 29, Issue 2 (31 Aug. 2016), pp.13-22, 10 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2016-08-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
- Physiological effects
- Bones
- Zinc
- Receptors(biochemistry)
- Cytokines
- Coumestrol
- Resorption(Physiology)
- Isoflavones
Abstract EN
Several observations have showed the synergistic effect of nutrients elements and phytoestrogens on bone resorption elimination.
Zn is one of the trace elements found to increase the stimulatory effect of phytoestrogens including genestein, coumestrol and daidzein on bone formation; however the synergistic modulation of Zn, genestein, coumestrol and daidzein on proinflammatory-producing T-cells and receptor activator of NFκB ligand (RANKL) expression that implicated in osteoclast formation is still open area to debate.
This study found that Zn enhanced the inhibitory effect of genistein, daidzein and coumestrol on TNF-α expression; however the same effect was shown with daidzein on IL-1β expression while there is no further effect found with other compounds.
Zn is only in combination with genistein decreaseIL-6 expression; moreover Zn had additional effect on the inhibitory effect of all test phytoestrogens on RANKL expression in dose-dependent manner.
In conclusion, Zn alone or in combination with phytoestrogens has an inhibitory effect on the expression of pro-inflammatory cytokines and RANKL that play an important role in the promotion of bone resorption.
American Psychological Association (APA)
Gharib, Sahar Sadi. 2016. The synergistic effect of zinc, coumestrol, genestein and daidzein on proinflammatory cytokines production and receptor activator of NFκB ligand expression that implicates in bone resorption. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 29, no. 2, pp.13-22.
https://search.emarefa.net/detail/BIM-745844
Modern Language Association (MLA)
Gharib, Sahar Sadi. The synergistic effect of zinc, coumestrol, genestein and daidzein on proinflammatory cytokines production and receptor activator of NFκB ligand expression that implicates in bone resorption. Ibn al-Haitham Journal for Pure and Applied Science Vol. 29, no. 2 (2016), pp.13-22.
https://search.emarefa.net/detail/BIM-745844
American Medical Association (AMA)
Gharib, Sahar Sadi. The synergistic effect of zinc, coumestrol, genestein and daidzein on proinflammatory cytokines production and receptor activator of NFκB ligand expression that implicates in bone resorption. Ibn al-Haitham Journal for Pure and Applied Science. 2016. Vol. 29, no. 2, pp.13-22.
https://search.emarefa.net/detail/BIM-745844
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 19-21
Record ID
BIM-745844