From therapeutic drug monitoring to drug management : IMPDH activity as novel surrogate marker for dose adjustment of Mycophenolate in immunosuppressive therapy
Other Title(s)
من مناطرة الدواء العلاجية إلى التدبير الدوائي : فاعلية IMPDH كواصم جديد بديل لضبط جرعة الميكوفينولات في العلاج الكابت للمناعة
Joint Authors
Source
The Journal of Clinical Laboratory
Issue
Vol. 8, Issue 1-2 (31 Jul. 2016), pp.91-99, 9 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2016-07-31
Country of Publication
Syria
No. of Pages
9
Main Subjects
Topics
Abstract EN
Background : Mycophenolic acid is a well established inhibitor of inosine-monophosphate-dehydrogenase (IMPDH) in immunosuppressive therapy.
Adverse side effects require dose reduction in more than half of the patients, increasing the risk for acute rejection.
Unlike for other immunosuppressants, measuring the trough level shows no relevant correlation to the risk of graft loss.
Instead, we determined the residual IMPDH activity, aiming on suggesting trusted intervals for drug management in the context of dose-reduction.
Materials and Methods: IMPDH activity (pmol/s per pmol AMP) was measured in 276 stable patients after renal transplantation.
Results : A mean overall residual activity of 38.9 ± 45.9 pmol/s pmol AMP (median = 28 pmol/s pmol AMP) was derived from 2505 individual measurements; the 10th percentile equaled 5 pmol/s pmol AMP, the 90th percentile 78 pmol/s pmol AMP.
Conclusion: Measurement of IMPDH activity in renal transplantation patients adds valuable information on the degree of immunosuppression
American Psychological Association (APA)
Kupper, Manfred& Hallaq, Rana. 2016. From therapeutic drug monitoring to drug management : IMPDH activity as novel surrogate marker for dose adjustment of Mycophenolate in immunosuppressive therapy. The Journal of Clinical Laboratory،Vol. 8, no. 1-2, pp.91-99.
https://search.emarefa.net/detail/BIM-746602
Modern Language Association (MLA)
Kupper, Manfred& Hallaq, Rana. From therapeutic drug monitoring to drug management : IMPDH activity as novel surrogate marker for dose adjustment of Mycophenolate in immunosuppressive therapy. The Journal of Clinical Laboratory Vol. 8, no. 1-2 (Jul. 2016), pp.91-99.
https://search.emarefa.net/detail/BIM-746602
American Medical Association (AMA)
Kupper, Manfred& Hallaq, Rana. From therapeutic drug monitoring to drug management : IMPDH activity as novel surrogate marker for dose adjustment of Mycophenolate in immunosuppressive therapy. The Journal of Clinical Laboratory. 2016. Vol. 8, no. 1-2, pp.91-99.
https://search.emarefa.net/detail/BIM-746602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 96-99
Record ID
BIM-746602