Renal function tests in hypertensive patients using CAPTOPRIL

Abstract EN

Objective : To study the renal function tests in hypertensive patients using captopril and comparing the results with that observed in newly diagnosed untreated hypertensive patients.

In addition comparing these results with results of apparently normal residents living in Mosul city as a control group.

Methods : Eighty essential hypertensive patients were included in this study.

They were divided into two groups, the first group included 50 patients (called group A), with ages ranged from 37-62 years and a mean of 47.86 years, all were used captopril as antihypertensive therapy.

The second group included 30 patients of newly diagnosed untreated hypertensive patients (called group B), with ages ranged from 36-57 years with a mean of 44.9 years.

A third group was the control group (called group C), consisted of 30 normotensive subjects with ages ranged from 35-58 years with a mean of 45.9 years.

The biochemical investigations carried were the renal function tests including serum urea, creatinine, creatinine clearance, uric acid, sodium and potassium in addition to urine microalbuminuria.

Results : The results of the present study showed that serum uric acid level was significantly lower in group A in comparison with group C.

In addition, microalbuminuria level was significantly higher in group A in comparison to group C.

The results of this study also showed that serum urea level, serum uric acid level and microalbuminuria were significantly higher in group B in comparison with group C.

This study also included the effect age on the renal function tests and showed a significant decrease in creatinine clearance and a significant increase in microalbuminuria level in the samples of the group A in comparison to the group C.

Whereas, the effect of the dose and the duration of treatment in both cases on the renal function tests showed significant increase in microalbuminuria level in comparison with group C.

Conclusions : The overall analysis of renal function tests indicates that captopril is relatively safe antihypertensive drug with mild undesirable effects, and it seems to be suitable antihypertensive drug for patients with microalbuminuria, and/or with high serum uric acid level as it indicates improvement in these parameters.