Serum levels of IL-8 in children with idiopathic nephrotic syndrome relapse

Abstract EN

Objective : Several findings suggest the role of the immune system in patients with idiopathic nephrotic syndrome (INS).

To disclose possible changes that might contribute to the pathogenesis of this syndrome, the present study aimed to evaluate specifically serum levels of IL-8.

Methods : The concentration of IL-8 were measured by ELISA in serum of 80 children with steroid sensitive idiopathic nephrotic syndrome during relapse who attending Children Welfare Teaching Hospital Consultation Clinic, Baghdad medical complex city, their ages ranged between 1-15 years, median 3.4 years, another 20 healthy age-matched controls were included in the study.

Results: We found significantly higher levels of IL-8 in the serum of relapsing children with steroid sensitive idiopathic nephrotic syndrome compared to controls.

Conclusions : IL-8 may have a role in the pathogenesis of idiopathic nephrotic syndrome in children.