تحري أوجه التوسع الوعائي لخلاصة الأخيلية مقارنة بموسعات وعائية دوائية
Other Title(s)
Detection the vasodilator aspects of achillea fragrantissima ethanolic extract in comparison with vasodilator drugs
Joint Authors
الأغواني، وائل
اللحام، أنطون
الماضي، سوسن
Source
Issue
Vol. 28, Issue 1 (30 Jun. 2012), pp.195-208, 14 p.
Publisher
Publication Date
2012-06-30
Country of Publication
Syria
No. of Pages
14
Main Subjects
Abstract EN
The background and the aim: The vasodilator effect of ethanolic extract of Achillea Fragrantissima (Asteraceae) was detected at several levels in isolated and phenylephrine- precontracted rabbit aortic rings.
Materials and methods: First, The role of potassium channels and β2 receptors was determined by using the selective blockers for each of them: Charybdotoxine and Propranolol, respectively.
Secondly, there was a set of experiments in which a Ca+2 free Krebs solution was used and pheylephrine contracted the rings following by re-injection of Ca+2 ions to the medium, this step was repeated in the presence of the extract.
The vasodilator drugs: Diltiazem and Prazocine were used as reference and for evaluation.
Results: This extract showed a profound relaxing effect on phenylephrine- precontracted aortic rings, which was partially related to potassium channels and β2 receptors.
In experiments that used Ca+2 free Krebs solution, the extract inhibited partially the first phase contraction (pheylephrine contraction) and the second phase contraction which is due for calcium entry via calcium channels, with more potent for the last one and this was similar to Diltiazem.
Conclusion: the vasodilator effect of ethanolic extract of Achillea Fragrantissima is largely related to calcium channels and this emphasis the need for isolation of related compound(s)
American Psychological Association (APA)
الأغواني، وائل والماضي، سوسن واللحام، أنطون. 2012. تحري أوجه التوسع الوعائي لخلاصة الأخيلية مقارنة بموسعات وعائية دوائية. مجلة جامعة دمشق للعلوم الطبية،مج. 28، ع. 1، ص ص. 195-208.
https://search.emarefa.net/detail/BIM-747242
Modern Language Association (MLA)
الأغواني، وائل....[و آخرون]. تحري أوجه التوسع الوعائي لخلاصة الأخيلية مقارنة بموسعات وعائية دوائية. مجلة جامعة دمشق للعلوم الطبية مج. 28، ع. 1 (2012)، ص ص. 195-208.
https://search.emarefa.net/detail/BIM-747242
American Medical Association (AMA)
الأغواني، وائل والماضي، سوسن واللحام، أنطون. تحري أوجه التوسع الوعائي لخلاصة الأخيلية مقارنة بموسعات وعائية دوائية. مجلة جامعة دمشق للعلوم الطبية. 2012. مج. 28، ع. 1، ص ص. 195-208.
https://search.emarefa.net/detail/BIM-747242
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 208
Record ID
BIM-747242