Immunological profile in different groups of end stage renal disease
Joint Authors
Ahmad, Zahra Ali
Salih, Madha Muhammad Shit
Source
al-Kufa University Journal for Biology
Issue
Vol. 8, Issue 3 (31 Dec. 2016), pp.245-252, 8 p.
Publisher
University of Kufa Faculty of Science Department of live Sciences
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background and aim of study: End Stage Renal Disease (ESRD) is a worldwide problem in which patients are in hemo-dialysis and/or awaiting for kidney transplantation.
However, the actual mechanism (s) of ESRD pathogenesis is ill-defined.
The aim of this study is to investigate the role of certain immunological markers in the pathogenesis of ESRD.
Materials and methods: Sixty eight blood samples were collected from hospitalized ESRD patients with different etiology (hypertensive, diabetics, hypertensive + diabetics, and small size kidney).
Twenty healthy volunteers as control group was enrolled in the study.
Serum IL-10, IL-17, MCP-1 and TGF-β were estimated in all subjects.
Result: A significant elevation in the serum IL-10, MCP-1 and IL-17 mean concentration in all ESRD patients groups.
TGF-β mean concentration exhibited decreasing level in the hypertensive, hypertensive + diabetes and small size kidney groups and a slight elevation in the diabetes group.
The IL-10: IL-17 ratio expressed elevation in all ESRD patients groups.
Conclusion: There is a progress of inflammatory reactions in all ESRD patients groups in which IL-17 and MCP-1 are playing major roles.
TGF-β1 is not played its anticipated pro-fibrotic role and anti-inflammatory function in the studied group.
The ratio of IL-10: IL-17 point out a slight shifting of the immunosuppressive reaction over the inflammatory reaction in all ESRD patients groups.
American Psychological Association (APA)
Salih, Madha Muhammad Shit& Ahmad, Zahra Ali. 2016. Immunological profile in different groups of end stage renal disease. al-Kufa University Journal for Biology،Vol. 8, no. 3, pp.245-252.
https://search.emarefa.net/detail/BIM-747280
Modern Language Association (MLA)
Salih, Madha Muhammad Shit& Ahmad, Zahra Ali. Immunological profile in different groups of end stage renal disease. al-Kufa University Journal for Biology Vol. 8, no. 3 (2016), pp.245-252.
https://search.emarefa.net/detail/BIM-747280
American Medical Association (AMA)
Salih, Madha Muhammad Shit& Ahmad, Zahra Ali. Immunological profile in different groups of end stage renal disease. al-Kufa University Journal for Biology. 2016. Vol. 8, no. 3, pp.245-252.
https://search.emarefa.net/detail/BIM-747280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 250-252
Record ID
BIM-747280