Frequency of IgM and IgG antibodies against Toxoplasma gondii, cytomegalovirus and rubella virus in serum specimens from aborted women in North Baghdad-al-Tarmiya region

Abstract EN

Background: Prenatal screening for evaluation the frequency of IgM & IgG antibodies against Toxoplasma gondii (T.

gondii), Rubella virus and Cytomegalovirus (CMV) infections is an important test in this work.

The acute infections which are caused by Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) during pregnancy often associated with adverse fetal outcomes and reproductive failures.

Toxoplasma, Rubella and CMV are known to cause infection in uterus and are often responsible for abortion, stillbirth, premature delivery and congenital malformation.

Detection and timely treatment of such infections can prevent morbidity and mortality of the infants born to such mothers.

Objective : The present study was undertaken to screening and evaluation the frequency of IgM & IgG antibodies against Toxoplasma gondii, Cytomegalovirus (CMV) and Rubella virus infections in blood samples collected from aborted women lived in North Baghdad Al-Tarmiya region.

Materials and Methods: Sera were collected from aborted women and they were tested for the presence of specific IgM& IgG antibodies against the Toxoplasma gondii, Cytomegalovirus (CMV) and Rubella virus infections by ELISA.

This study was performed in North Baghdad Al-Tarmiya region from the period of April /2013 to July/2013.

Results: It was shown (table-2) that the highest frequency of specific IgM and IgG anti- Toxoplasma gondii (T.

gondii), Rubella virus and Cytomegalovirus antibodies was recorded in the age group between 19 to 45 years, 78% and 28%, respectively.

According to abortion frequency, IgM was recorded the highest frequency (63.26%) in the Toxoplasma infections, followed by IgM anti-CMV infections was(18.4%) and then IgM anti-Rubella infections was (5.1%) as explain in (table-3).

The present study revealed that the highest frequency of IgM & IgG anti-under research infections antibodies was detected in the first trimester of pregnancy as explain in (table-4).

Conclusions: It was concluded that seropositivity of IgM anti- Toxoplasma gondii (T.

gondii), Rubella virus and Cytomegalovirus antibodies was higher than that observed with IgG in blood samples collected from aborted women lived in North Baghdad-Al-Tarmiya region.

Recommendations: A large size of sample is recommended to be studied to confirm the results of this study.

All the antenatal cases should be routinely screened to detection Toxoplasma gondii (T.

gondii), Rubella virus and Cytomegalovirus infections, for early treatment to prevent fetal loss.