The role of helicobacter pylori as a risk factor for hyperemesis gravidarum and its management

Abstract EN

Background: Hyperemesis gravidarum is a disease of severe nausea, vomiting and anorexia associated with early pregnancy leading to dehydration and weight loss which occurs in approximately 0.3-2% of pregnancies.

The principal condition to diagnose hyperemesis gravidarum is the presence of three or more vomiting episodes during the day, weight loss of over 5% and ketonuria.

The problem is generally time limited with onset about the fifth week after the last menstrual period, a peak at about 8-12 weeks, and resolution by 16-18 weeks for most women.

The factors associated with hyperemesis are primarily medical and fetal factors.

In the last years, association between Helicobacter Pylori and hyperemesis gravidarum has been found and serologically positive H.

Pylori infection has been demonstrated in the hyperemesis patients.

Objective: To determine the role of Helicobacter Pylori as a risk factor of Hyperemesis Gravidarum, the role of adding non teratogenic regimen for its treatment, the role of Ondansetrone for treatment of resistant cases.

Methods: The study include 80 women, Group (1) 40 women with Hyperemesis Gravidarum and Group (2) 40 women with usual antenatal care.

Serum H Pylori Ig G titre was measured for detection of incidence of seropositivety in both groups.

the efficacy of Helicobacter treatment was determined in seropositive cases.

The effect of Ondansetrone treatment was detected in resistant cases in both groups.

Results: Regarding H Pylori seropositivety there was significant difference between study group 27 (67,5%) and control groups 14 (35%).

Regarding the efficacy of H Pylori treatment in seropositive cases that resist the usual treatment there was