اشتراكات المستضد HLA-DR، و المستضد HLA-DQ في الإسقاطات المتكررة لنساء من المجتمع السوري

Abstract EN

Background: Many available references indicate to a role for HLA-antigens in recurrent abortions , during their function in self and non-self recognition.

The embryo, being hemi-allograft, make it rational to search for some HLA-antigens more frequent in women suffering from recurrent abortions in Syrian population , especially HLA-II antigens HLA-II antigens.

Searching also for combined haplotypes between these antigens.

We did not found any like study in Syrian population .

Materials and methods : The Antigens types of HLA-DR and HLA-DQ of (14) fertile multifarious Syrian couples( controls) were defined by micro lymphocytotoxicity test( Terazaki method).

In the same time, antigen types of DR and DQ of (36) Healthy Syrian couples suffering from recurrent abortions were defined by the same technique.

The Results: The results indicate different antigen pattern distribution between control and diseased groups.

The frequencies in control group for DR types were ase the following : DR4:29%, DR11:18% , DR15:14% , DR1: 7% , DR7: 7% , DR8: 7% , DR16: 7%, DR3: 4% ,DR12: 4% , DR14: 4% .

And in the diseased group were : DR4:18% , DR11:18% , DR7: 11% , DR1 : 10% , DR14: 7% , DR17: 7% , DR13: 6% , DR15: 6% , DR8: 6% , DR3: 4% , DR12: 3% , DR9: 1% , DR10: 1% , DR16: 1% , DR18: 1% .The frequencies in control group for DQ types were: DQ3: 29% , DQ4: 25% , DQ5: 21 % DQ2: 14% , DQ6: 11% .

And in the diseased group were : DQ3: 28% , DQ5: 25% , DQ2: 18% , DQ4: 15% , DQ6: 14% .

The obvious frequency changes for DR types were : DR1, DR7 , DR4, D15, DR13, DR17, DR14 .

and for DQ types were : DQ2 , DQ4 , DQ5, DQ6.

Conclusions: The differences of DR -DQ types distributions in the studied group of control (women and men ) are similar to those in other studies in the Syrian population .

This study suggest that having antigen types of DR-DQ in frequencies different from control observed in the whole population make them at risk to inconvenient immunological response to accept pregnancy the result of which is abortion.