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اشتراكات المستضد HLA-DR، و المستضد HLA-DQ في الإسقاطات المتكررة لنساء من المجتمع السوري
Other Title(s)
HLA-DR DQ antigens associations in recurrent abortions for women from Syrian population
Author
Source
Issue
Vol. 28, Issue 1 (30 Jun. 2012), pp.243-261, 19 p.
Publisher
Publication Date
2012-06-30
Country of Publication
Syria
No. of Pages
19
Main Subjects
Abstract EN
Background: Many available references indicate to a role for HLA-antigens in recurrent abortions , during their function in self and non-self recognition.
The embryo, being hemi-allograft, make it rational to search for some HLA-antigens more frequent in women suffering from recurrent abortions in Syrian population , especially HLA-II antigens HLA-II antigens.
Searching also for combined haplotypes between these antigens.
We did not found any like study in Syrian population .
Materials and methods : The Antigens types of HLA-DR and HLA-DQ of (14) fertile multifarious Syrian couples( controls) were defined by micro lymphocytotoxicity test( Terazaki method).
In the same time, antigen types of DR and DQ of (36) Healthy Syrian couples suffering from recurrent abortions were defined by the same technique.
The Results: The results indicate different antigen pattern distribution between control and diseased groups.
The frequencies in control group for DR types were ase the following : DR4:29%, DR11:18% , DR15:14% , DR1: 7% , DR7: 7% , DR8: 7% , DR16: 7%, DR3: 4% ,DR12: 4% , DR14: 4% .
And in the diseased group were : DR4:18% , DR11:18% , DR7: 11% , DR1 : 10% , DR14: 7% , DR17: 7% , DR13: 6% , DR15: 6% , DR8: 6% , DR3: 4% , DR12: 3% , DR9: 1% , DR10: 1% , DR16: 1% , DR18: 1% .The frequencies in control group for DQ types were: DQ3: 29% , DQ4: 25% , DQ5: 21 % DQ2: 14% , DQ6: 11% .
And in the diseased group were : DQ3: 28% , DQ5: 25% , DQ2: 18% , DQ4: 15% , DQ6: 14% .
The obvious frequency changes for DR types were : DR1, DR7 , DR4, D15, DR13, DR17, DR14 .
and for DQ types were : DQ2 , DQ4 , DQ5, DQ6.
Conclusions: The differences of DR -DQ types distributions in the studied group of control (women and men ) are similar to those in other studies in the Syrian population .
This study suggest that having antigen types of DR-DQ in frequencies different from control observed in the whole population make them at risk to inconvenient immunological response to accept pregnancy the result of which is abortion.
American Psychological Association (APA)
حراتة، ملك. 2012. اشتراكات المستضد HLA-DR، و المستضد HLA-DQ في الإسقاطات المتكررة لنساء من المجتمع السوري. مجلة جامعة دمشق للعلوم الطبية،مج. 28، ع. 1، ص ص. 243-261.
https://search.emarefa.net/detail/BIM-747477
Modern Language Association (MLA)
حراتة، ملك. اشتراكات المستضد HLA-DR، و المستضد HLA-DQ في الإسقاطات المتكررة لنساء من المجتمع السوري. مجلة جامعة دمشق للعلوم الطبية مج. 28، ع. 1 (2012)، ص ص. 243-261.
https://search.emarefa.net/detail/BIM-747477
American Medical Association (AMA)
حراتة، ملك. اشتراكات المستضد HLA-DR، و المستضد HLA-DQ في الإسقاطات المتكررة لنساء من المجتمع السوري. مجلة جامعة دمشق للعلوم الطبية. 2012. مج. 28، ع. 1، ص ص. 243-261.
https://search.emarefa.net/detail/BIM-747477
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 260-261
Record ID
BIM-747477