Synthesis and molecular modeling studies of novel pyrrole analogs as antimycobacterial agents
Joint Authors
Joshi, Shrinivas D.
More, Uttam A.
Pansuriya, Ketan
Aminabhavi, Tejraj M.
Gadad, Andanappa K.
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 1 (31 Jan. 2017), pp.42-57, 16 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
16
Main Subjects
Abstract EN
In the present investigation, a series of 4-(4-pyrrol-1-yl/2,5-dimethyl-4-pyrrol-1-yl) benzoic acid hydrazide analogs, some derived oxadiazoles and azines have been synthesized in good yields and structures of these compounds were established by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis.
The newly synthesized title compounds were evaluated for their antimicrobial as well as antimycobacterial activities.
Among the tested compounds, 6j and 9c displayed promising anti-tubercular activity.
Further, some compounds were also assessed for their cytotoxic activity (IC50) against mammalian Vero cell lines and A549 (lung adenocarcinoma) cell lines using the MTT assay method.
The results revealed that these compounds exhibit anti-tubercular activity at non-cytotoxic concentrations.
The docking of inhibitors into InhA using Sybyl-X 2.0 software revealed the vital interactions and binding conformation of the inhibitors.
American Psychological Association (APA)
Joshi, Shrinivas D.& More, Uttam A.& Pansuriya, Ketan& Aminabhavi, Tejraj M.& Gadad, Andanappa K.. 2017. Synthesis and molecular modeling studies of novel pyrrole analogs as antimycobacterial agents. Journal of Saudi Chemical Society،Vol. 21, no. 1, pp.42-57.
https://search.emarefa.net/detail/BIM-747649
Modern Language Association (MLA)
Joshi, Shrinivas D.…[et al.]. Synthesis and molecular modeling studies of novel pyrrole analogs as antimycobacterial agents. Journal of Saudi Chemical Society Vol. 21, no. 1 (Jan. 2017), pp.42-57.
https://search.emarefa.net/detail/BIM-747649
American Medical Association (AMA)
Joshi, Shrinivas D.& More, Uttam A.& Pansuriya, Ketan& Aminabhavi, Tejraj M.& Gadad, Andanappa K.. Synthesis and molecular modeling studies of novel pyrrole analogs as antimycobacterial agents. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 1, pp.42-57.
https://search.emarefa.net/detail/BIM-747649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 55-57
Record ID
BIM-747649