Synthesis and pharmacological activity of diorganoantimony(III) and triorganoantimony (V) derivatives of Schiff bases derived from amino acids
Joint Authors
Sharma, Jyoti
Gupta, Rita
Mathur, Manas
Swami, Ajit Kumar
Singh, Yashpal
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 1 (31 Jan. 2017), pp.67-75, 9 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
Some new diorganoantimony(III) and triorganoantimony(V) compounds of Schiff bases derived from amino acids having the general formula Ph2Sb[OC(R)CHC(R0)NC(Y) COOH] [where R=CH3, R0 =C6H5, Y=AH2CH2(1), -H2C6H5(2); R = R0 =C6H5, Y=AH2CH2(3), AHCH2C6H5(4)] have been synthesized by the reaction of Ph3Sb with RC (O) CHC(R0) NHC(Y) COOH in 1:1 M ratio.
Whereas Ph3Sb[OC(R)CHC(R0)NC(Y) COOH]2 (where R= CH3, R0 = C6H5, Y=AH2CH2(5), R= R0 =C6H5, Y=AHCH2C6H5(6)) have been synthesized by the reactions of Ph3SbBr2 with Na [OC(R) CHC(R0)NC(Y) COOH] in 1:2 M ratio, respectively in anhydrous benzene.
All these compounds have been characterized by elemental analyses and molecular weight measurement.
Probable structures of these compounds have been proposed on the basis of spectral studies (I.R.
1H and 13C NMR).
Schiff base (R= CH3 R0 =C6H5, Y=AH2CH2) and its corresponding organoantimony(III) and -antimony(V) compounds have been screened for antimicrobial, antioxidant and antiplatelet activities.
These synthesized compounds can be used as new class of antimicrobial, antioxidant and antiplatelet agents with potential for clinical development.
American Psychological Association (APA)
Gupta, Rita& Mathur, Manas& Swami, Ajit Kumar& Sharma, Jyoti& Singh, Yashpal. 2017. Synthesis and pharmacological activity of diorganoantimony(III) and triorganoantimony (V) derivatives of Schiff bases derived from amino acids. Journal of Saudi Chemical Society،Vol. 21, no. 1, pp.67-75.
https://search.emarefa.net/detail/BIM-747650
Modern Language Association (MLA)
Gupta, Rita…[et al.]. Synthesis and pharmacological activity of diorganoantimony(III) and triorganoantimony (V) derivatives of Schiff bases derived from amino acids. Journal of Saudi Chemical Society Vol. 21, no. 1 (Jan. 2017), pp.67-75.
https://search.emarefa.net/detail/BIM-747650
American Medical Association (AMA)
Gupta, Rita& Mathur, Manas& Swami, Ajit Kumar& Sharma, Jyoti& Singh, Yashpal. Synthesis and pharmacological activity of diorganoantimony(III) and triorganoantimony (V) derivatives of Schiff bases derived from amino acids. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 1, pp.67-75.
https://search.emarefa.net/detail/BIM-747650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 74-75
Record ID
BIM-747650