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New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells
Joint Authors
Ahmad, Aamir
Mahal, Katharina
Padhye, Subhash
Schobert, Rainer
Biersack, Bernhard
Sarkar, Fazlul H.
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 1 (31 Jan. 2017), pp.105-110, 6 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Lawsone (1a) is a known naphthoquinone dye from the Henna plant Lawsonia inermis.
Out of a series of four new ferrocene modified Mannich bases of 1a, the 2-pyridyl derivative 2a was distinctly more active than its analogs 2b–d in breast, prostate and pancreatic cancer cells.
2a also exhibited greater antiproliferative effects when compared with the known anticancer active Mannich bases 1b and 1c in the androgen-receptor negative PC-3 prostate and Pgp-expressing KB-V1/Vbl cervix carcinoma cell lines.
Compound 2a reached sub-micromolar activities in these aggressive cancer cells and, thus, features a promising drug candidate for the efficient treatment of hormone- or multidrug-resistant cancer types
American Psychological Association (APA)
Ahmad, Aamir& Mahal, Katharina& Padhye, Subhash& Sarkar, Fazlul H.& Schobert, Rainer& Biersack, Bernhard. 2017. New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells. Journal of Saudi Chemical Society،Vol. 21, no. 1, pp.105-110.
https://search.emarefa.net/detail/BIM-747657
Modern Language Association (MLA)
Ahmad, Aamir…[et al.]. New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells. Journal of Saudi Chemical Society Vol. 21, no. 1 (Jan. 2017), pp.105-110.
https://search.emarefa.net/detail/BIM-747657
American Medical Association (AMA)
Ahmad, Aamir& Mahal, Katharina& Padhye, Subhash& Sarkar, Fazlul H.& Schobert, Rainer& Biersack, Bernhard. New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 1, pp.105-110.
https://search.emarefa.net/detail/BIM-747657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 109-110
Record ID
BIM-747657