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Is the ratio of antibodies against oxidized LDL to oxidized LDL an indicator of cardiovascular risk in psoriasis ?
Joint Authors
Sunitha S.
Rajappa, Medha
Thappa, Devinder Mohan
Chandrashekar, Laxmisha
Munisamy, Malathi
Revathy, G.
Source
Issue
Vol. 31, Issue 5 (30 Sep. 2016), pp.390-393, 4 p.
Publisher
Publication Date
2016-09-30
Country of Publication
Oman
No. of Pages
4
Main Subjects
Abstract EN
Objectives : Psoriasis is a chronic inflammatory skin disease.
Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity.
This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized LDL (anti-ox-LDL) and compute the ratio of anti-ox-LDL/ ox-LDL as a single composite parameter to assess the oxidative lipoprotein burden as an indicator of cardiovascular risk in patients with psoriasis.
Methods: This cross-sectional study included 45 patients with psoriasis.
All patients were given a psoriasis severity index score and their ox-LDL and anti-ox-LDL estimated using ELISA.
Results: The results of this study show an elevation in the ratio of anti-ox-LDL to ox-LDL in patients with psoriasis, which initiate and perpetuate the pathogenesis of psoriasis and its comorbidity, atherosclerotic cardiovascular disease.
Conclusions: Our results suggest that an elevated ratio of anti-ox-LDL/ox-LDL can serve as a composite parameter reflecting the total oxidative lipoprotein burden and cardiovascular risk in psoriasis patients.
American Psychological Association (APA)
Sunitha S.& Rajappa, Medha& Thappa, Devinder Mohan& Chandrashekar, Laxmisha& Munisamy, Malathi& Revathy, G.. 2016. Is the ratio of antibodies against oxidized LDL to oxidized LDL an indicator of cardiovascular risk in psoriasis ?. Oman Medical Journal،Vol. 31, no. 5, pp.390-393.
https://search.emarefa.net/detail/BIM-748732
Modern Language Association (MLA)
Sunitha S.…[et al.]. Is the ratio of antibodies against oxidized LDL to oxidized LDL an indicator of cardiovascular risk in psoriasis ?. Oman Medical Journal Vol. 31, no. 5 (Sep. 2016), pp.390-393.
https://search.emarefa.net/detail/BIM-748732
American Medical Association (AMA)
Sunitha S.& Rajappa, Medha& Thappa, Devinder Mohan& Chandrashekar, Laxmisha& Munisamy, Malathi& Revathy, G.. Is the ratio of antibodies against oxidized LDL to oxidized LDL an indicator of cardiovascular risk in psoriasis ?. Oman Medical Journal. 2016. Vol. 31, no. 5, pp.390-393.
https://search.emarefa.net/detail/BIM-748732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 392-393
Record ID
BIM-748732