Small cell variant of T-cell prolymphocytic leukemia with acquired palmoplantar keratoderma and cutaneous infiltration
Joint Authors
al-Musalhi, Buthaynah
Shihatah, Nansi
Billick, Robin
Source
Issue
Vol. 31, Issue 1 (31 Jan. 2016), pp.73-76, 4 p.
Publisher
Publication Date
2016-01-31
Country of Publication
Oman
No. of Pages
4
Main Subjects
Abstract EN
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive post-thymic malignancy that is characterized by the proliferation of small- to medium- sized prolymphocytes.
The classic clinical features of T-PLL are lymphocytosis, lymphadenopathy, hepatosplenomegaly, and skin lesions.
Skin involvement varies clinically from diffuse infiltrated erythema.
Infiltration is localized to the face and ears, nodules, and erythroderma.
We present a case of small cell variant of T-PLL in a patient who presented with unusual cutaneous manifestations of acquired palmoplantar keratoderma (PPK) followed by diffuse erythematous infiltrated papules and plaques involving the trunk.
When the etiology of acquired PPK is not clear, the physician should consider the possibility of an underlying malignant disease.
In this case, the diagnosis of T-PLL was subsequently confirmed by laboratory and cytological findings, as well as by the immunophenotyping of leukemic cells in skin biopsy.
Since paraneoplastic acquired PPK may be the initial evident sign of malignancy, the physician’s awareness of this manifestation may be crucial for early diagnosis and treatment.
Our case emphasizes the importance of accurate evaluation of skin lesions and early skin biopsy in the diagnosis of some hematological malignancies.
American Psychological Association (APA)
al-Musalhi, Buthaynah& Shihatah, Nansi& Billick, Robin. 2016. Small cell variant of T-cell prolymphocytic leukemia with acquired palmoplantar keratoderma and cutaneous infiltration. Oman Medical Journal،Vol. 31, no. 1, pp.73-76.
https://search.emarefa.net/detail/BIM-748761
Modern Language Association (MLA)
al-Musalhi, Buthaynah…[et al.]. Small cell variant of T-cell prolymphocytic leukemia with acquired palmoplantar keratoderma and cutaneous infiltration. Oman Medical Journal Vol. 31, no. 1 (Jan. 2016), pp.73-76.
https://search.emarefa.net/detail/BIM-748761
American Medical Association (AMA)
al-Musalhi, Buthaynah& Shihatah, Nansi& Billick, Robin. Small cell variant of T-cell prolymphocytic leukemia with acquired palmoplantar keratoderma and cutaneous infiltration. Oman Medical Journal. 2016. Vol. 31, no. 1, pp.73-76.
https://search.emarefa.net/detail/BIM-748761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 76
Record ID
BIM-748761