The relationship between mean platelet volume and neutrophil lymphocyte ratio with inflammation and proteinuria in chronic kidney disease
Joint Authors
Yilmaz, Gulay
Sevinc, Can
Ustundag, Sedat
Yavuz, Yasamin Coskun
Hacıbekiroglu, Tuba
Hatipoglu, Isra
Baysal, Mehmet
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 1 (28 Feb. 2017), pp.90-94, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-02-28
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbidity and mortality in chronic kidney disease (CKD).
In this study, we investigated the relationship of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with inflammation and proteinuria in patients with CKD Stage 3-4.
Healthy individuals who applied to nephrology clinic for checkup purposes acted as controls.
Fifty-three patients and 30 healthy controls were included in the study.
Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded from the study.
Biochemistry values and hemograms were recorded for all patients and for control group.
NLR was calculated.
The relationship between MPV/NLR and protein, fibrinogen, and proteinuria was evaluated.
Our study showed a statistically significant difference between CKD group and healthy control (HC) group in uric acid, fibrinogen, C-reactive protein, and NLR values (P <0.01, P <0.01, P = 0.01, P <0.01, respectively).
No statistically significant difference was found between CKD and HC groups for MPV (P = 0.307).
Correlation analysis revealed a statistically significant relationship between NLR and creatinine (P <0.00, r = 0.571), uric acid (P <0.00, r = 0.436), glomerular filtration rate (P <0.00, r = −0.418), 24 h urine protein (P = 0.004, r = 0.311), and 24 h urine microalbumin (P = 0.001, r = 0.354).
A statistically significant relationship was detected between MPV and platelet count (P <0.001, r = −0.422), age (P = 0.004, r = −0.312), uric acid (P = 0.04, r = −0.226), and fibrinogen (P = 0.023, r = −0.249).
Whereas, a statistically significant relationship was detected between NLR and microalbuminuria/proteinuria, there was no statistically significant relationship between MPV and microalbuminuria/proteinuria.
Our study showed that the NLR is high in CKD group and is correlated with uric acid and proteinuria, which are known to be associated with atherosclerosis, in patients with CKD.
NLR may be a determinant of inflammation and atherosclerosis in patients with CKD.
American Psychological Association (APA)
Yilmaz, Gulay& Sevinc, Can& Ustundag, Sedat& Yavuz, Yasamin Coskun& Hacıbekiroglu, Tuba& Hatipoglu, Isra…[et al.]. 2017. The relationship between mean platelet volume and neutrophil lymphocyte ratio with inflammation and proteinuria in chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 1, pp.90-94.
https://search.emarefa.net/detail/BIM-748872
Modern Language Association (MLA)
Yilmaz, Gulay…[et al.]. The relationship between mean platelet volume and neutrophil lymphocyte ratio with inflammation and proteinuria in chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 1 (Jan. / Feb. 2017), pp.90-94.
https://search.emarefa.net/detail/BIM-748872
American Medical Association (AMA)
Yilmaz, Gulay& Sevinc, Can& Ustundag, Sedat& Yavuz, Yasamin Coskun& Hacıbekiroglu, Tuba& Hatipoglu, Isra…[et al.]. The relationship between mean platelet volume and neutrophil lymphocyte ratio with inflammation and proteinuria in chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 1, pp.90-94.
https://search.emarefa.net/detail/BIM-748872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5
Record ID
BIM-748872