Correlation between oxidative stress and helicobacter pylori infection in gastric ulcer patient
Other Title(s)
العلاقة بين الأكسدة و الإصابة بالجرثومة الحلزونية في مرضى قرحة المعدة
Dissertant
al-Shwyilat, Saja Muhammad Malik
Thesis advisor
al-Mustafa, Ahmad Husayn Husayn
Comitee Members
al-Zariti, Wail Ali
al-Shurafa, Khalid Yusuf Ahmad
al-Dhunaybat, Usamah Yusuf
University
Mutah University
Faculty
Faculty of Science
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2017
English Abstract
Helicobacter pyloriinfection is known as one of the most common infection worldwide.
The aim of this study was to investigate the oxidative stress and biomarkers antioxidant enzymes systems in Helicobacter pyloripositive patients and normal.
Sixty four Helicobacter pyloripositive patients with a mean age of 34.8 years, who were diagnosed as Helicobacter pylori infected by immune test, and ten controls(mean age = 33.5 years) were also enrolled in the study.
Tests for complete blood count, serum and plasma lipid peroxide and total antioxidant (DPPH) capacity were performed in each patient in the study and control groups.
Also, the antioxidant enzymes ; superoxide dismutase (SOD), catalase ( CAT), glutathione peroxidase (GPX), glutathione reductase (GR) and glutathione transferases were evaluated.
Mean plasma DPPH levels were significantly lower in patients with Helicobacter pylori positive compared to control.
Also, this study showed a significant difference between the leukocytes, neutrophils (p≤ 0.02), lymphocytes(p≤ 0.05), Monocytes (p≤ 0.03), and eosinophils (p≤ 0.01) level of Helicobacter pyloripositive patients and control.Moreover, in the Helicobacter pyloripatients, the activities of superoxide dismutase and Catalase in blood were markedly higher than those of control group (P = 0.03 and P = 0.02, respectively).
Whereas, the activities of glutathione dependent enzymes; peroxidase, reductase and transferases in the Helicobacter pylori patients were significantly decreased compared to those of control group (P = 0.0001, P = 0.03 and P= 0.001 respectively).
Also, the mean values of lipid-peroxide (MDA) was significantly increased in the serum of Helicobacter pyloripatients (P = 0.02) and no significant difference in MDA level and total antioxidant activity in plasma of Helicobacter pyloripatients (P = 0.07 and P = 0.02), respectively.
Conclusions: The findings of this study suggest that Helicobacter pyloriinfection has an effect on oxidative stress markers and antioxidant enzymes activity and on levels the immune cells.
Main Subjects
Topics
No. of Pages
47
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Theoretical background.
Chapter Two : Literature review.
Chapter Three : Material and methodology.
Chapter Four : Result and discussion.
References.
American Psychological Association (APA)
al-Shwyilat, Saja Muhammad Malik. (2017). Correlation between oxidative stress and helicobacter pylori infection in gastric ulcer patient. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-749169
Modern Language Association (MLA)
al-Shwyilat, Saja Muhammad Malik. Correlation between oxidative stress and helicobacter pylori infection in gastric ulcer patient. (Master's theses Theses and Dissertations Master). Mutah University. (2017).
https://search.emarefa.net/detail/BIM-749169
American Medical Association (AMA)
al-Shwyilat, Saja Muhammad Malik. (2017). Correlation between oxidative stress and helicobacter pylori infection in gastric ulcer patient. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-749169
Language
English
Data Type
Arab Theses
Record ID
BIM-749169
