Developing a new microemulsion using nonionic surfactants for transdermal of diclofenac sodium

Other Title(s)

تطوير مستحلب دقيق باستخدام العوامل الفعالة على السطح الغير المتئينة بغرض التطبيق الجلدي لديكلوفنياك الصوديوم

Dissertant

al-Khudayri, Ala Hani Muhammad

Thesis advisor

al-Krad, Jamal Yusuf
al-Talhuni, Ahmad Ajud

Comitee Members

al-Khatib, Hatim Samir
Faraj, Jabbar A.

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2016

English Abstract

Transdermal drug delivery of diclofenac sodium can reduce gastric side effect, reduce number of doses by gaining sustained release through applying the drug transdermally, avoidance of first pass metabolism, and patient compliance can be improved.

Microemulsion is used to modify the drug delivery of the diclofenac sodium in terms of permeability from skin.

In this study, Span 20, Tween 80 was selected as surfactant and cosurfactant, isopropyl myristate was selected as lipophilic phase and a mixture of water and dimethyl sulfoxide as a hydrophilic phase.

Pseudo ternary diagrams were constructed.

The penetration though rat’s skin using franz diffusion cell for different developed diclofenac sodium loaded microemulsions with different hydrophilic phases amount, different amount of diclofenac sodium and using either Span 20 or mixture of Span 20 and Tween 80 were studied.

Cumulative amount of diclofenac sodium permeated per unit area in 24 hours was measured.

All formulation of drug loaded microemulsion was characterized for their viscosity characteristics and droplet sizes in range of colloidal dispersion system and high flux.

The highest flux value for diclofenac sodium through the skin for microemulsion formulation 5 was 223.51μg/hr.

Main Subjects

Pharmacology

No. of Pages

63

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-750373