Developing a new microemulsion using nonionic surfactants for transdermal of diclofenac sodium
Other Title(s)
تطوير مستحلب دقيق باستخدام العوامل الفعالة على السطح الغير المتئينة بغرض التطبيق الجلدي لديكلوفنياك الصوديوم
Dissertant
al-Khudayri, Ala Hani Muhammad
Thesis advisor
al-Krad, Jamal Yusuf
al-Talhuni, Ahmad Ajud
Comitee Members
al-Khatib, Hatim Samir
Faraj, Jabbar A.
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2016
English Abstract
Transdermal drug delivery of diclofenac sodium can reduce gastric side effect, reduce number of doses by gaining sustained release through applying the drug transdermally, avoidance of first pass metabolism, and patient compliance can be improved.
Microemulsion is used to modify the drug delivery of the diclofenac sodium in terms of permeability from skin.
In this study, Span 20, Tween 80 was selected as surfactant and cosurfactant, isopropyl myristate was selected as lipophilic phase and a mixture of water and dimethyl sulfoxide as a hydrophilic phase.
Pseudo ternary diagrams were constructed.
The penetration though rat’s skin using franz diffusion cell for different developed diclofenac sodium loaded microemulsions with different hydrophilic phases amount, different amount of diclofenac sodium and using either Span 20 or mixture of Span 20 and Tween 80 were studied.
Cumulative amount of diclofenac sodium permeated per unit area in 24 hours was measured.
All formulation of drug loaded microemulsion was characterized for their viscosity characteristics and droplet sizes in range of colloidal dispersion system and high flux.
The highest flux value for diclofenac sodium through the skin for microemulsion formulation 5 was 223.51μg/hr.
Main Subjects
No. of Pages
63
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
[Chapter One] : Introduction.
[Chapter Two] : Lecture review.
[Chapter Three] : Methodology.
[Chapter Four] : Results.
[Chapter Five] : Discussion.
[Chapter Six] : Conclusion.
References.
American Psychological Association (APA)
al-Khudayri, Ala Hani Muhammad. (2016). Developing a new microemulsion using nonionic surfactants for transdermal of diclofenac sodium. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-750373
Modern Language Association (MLA)
al-Khudayri, Ala Hani Muhammad. Developing a new microemulsion using nonionic surfactants for transdermal of diclofenac sodium. (Master's theses Theses and Dissertations Master). Isra University. (2016).
https://search.emarefa.net/detail/BIM-750373
American Medical Association (AMA)
al-Khudayri, Ala Hani Muhammad. (2016). Developing a new microemulsion using nonionic surfactants for transdermal of diclofenac sodium. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-750373
Language
English
Data Type
Arab Theses
Record ID
BIM-750373