Relationship between thyroid function, cystatin c and different oxidative stress in Iraqi patients with chronic kidney disease

Abstract EN

Chronic Kidney Disease (CKD) is associated with slightly higher frequency prevalence of primary hypothyroidism , but at the same studies on thyroid hormone status in uremic patients has reported conflicting results.

This study was undertaken during the period from February 2014 to January 2015to quantify thyroid hormones (T3,T4 and TSH) ,cystatin C, different oxidative stress parameters like serum Ceruloplasmin (CP), Carbonyl, Thiol and total protein (TP) and four trace elements (Molybdenum (Mo), Cadmium (Cd), Manganese (Mn) and Magnesium (Mg) and explore correlation between these parameters in (75) non- dialyzed CKD patients’ verses (52) healthy controls.

Results indicated that the levels of (T3, T4,CP, TP,thiol,Mo ,Cd and Mg were significantly reduced (p≤ 0.05)while the levels of TSH ,cystatin C ,carbonyl and Mnweremildly significantly increase(p≤ 0.05) in patients group compared to healthy controls.The correlation coefficient ( r ) test is used to describe the association between these parameters,T3 and T4 were negatively correlated with cystatin C ,carbonyl, Mn and Mg, positively correlated with(thiol and protein) .T4 positively correlated with CP while T3 not correlated with CP.TSH positively correlated with (CP, carbonyl,thiol,protein), finally, CP negatively correlated with cystatin C and positively correlated with Mn and Mg.