Impact of different doses of nicorandil-induced ulceration (Oral , Gastrointestinal Tract, and Anal) in rats : roles of leptin and prostaglandin E2
Other Title(s)
تأثير الجرع المختلفة في استحداث التقرح بواسطة عقار النيكوراندل (الفم، الجهاز الهضمي و الشرج) في الجرذان دور هرمون اللبتين و البروستاكلاندين E2
Joint Authors
Haydar, Asma Awni
al-Tai, Taghrid Siham
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 25, Issue 2 (31 Dec. 2016), pp.15-26, 12 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
Many reports confirm ulcers as an adverse effect of drugs such as nicorandil and aspirin.
The exact responsible mechanisms of ulceration have until now not proved.
Mucosal ulcers associated with the onset of ulcer are manifested by an increase in proinflammatory cytokine, excessive prostaglandin, and up-regulation of Endothilin-1 level, which directly impacts the release of leptin.
These, released locally within mucosal tissues, have played a role in controlling the extent of local inflammatory responses and processes of mucosal repair.
This study was designed to find out the correlation of plasma leptin and prostaglandin levels as a possible mechanism of oral ulcer formation as an adverse effect of nicorandil.
The effect of nicorandil for inducing ulceration was assessed.
The plasma leptin and prostaglandin E2 for the tested groups in relation to the studied parameters (gender, and daily body weight change) were estimated in albino rats.
Nicorandil causes mucous membrane damage, inflammation, and ulceration.
A significant reduction of plasma leptin level, which was dose-dependent, and a non-significant reduction of serum prostaglandin E2 level.
The mechanisms of ulcer induction as an adverse effect of nicorandil can be related to dose-dependant leptin and prostaglandin E2 levels, which affects on repair and healing process
American Psychological Association (APA)
Haydar, Asma Awni& al-Tai, Taghrid Siham. 2016. Impact of different doses of nicorandil-induced ulceration (Oral , Gastrointestinal Tract, and Anal) in rats : roles of leptin and prostaglandin E2. Iraqi Journal of Pharmaceutical Sciences،Vol. 25, no. 2, pp.15-26.
https://search.emarefa.net/detail/BIM-753132
Modern Language Association (MLA)
Haydar, Asma Awni& al-Tai, Taghrid Siham. Impact of different doses of nicorandil-induced ulceration (Oral , Gastrointestinal Tract, and Anal) in rats : roles of leptin and prostaglandin E2. Iraqi Journal of Pharmaceutical Sciences Vol. 25, no. 2 (2016), pp.15-26.
https://search.emarefa.net/detail/BIM-753132
American Medical Association (AMA)
Haydar, Asma Awni& al-Tai, Taghrid Siham. Impact of different doses of nicorandil-induced ulceration (Oral , Gastrointestinal Tract, and Anal) in rats : roles of leptin and prostaglandin E2. Iraqi Journal of Pharmaceutical Sciences. 2016. Vol. 25, no. 2, pp.15-26.
https://search.emarefa.net/detail/BIM-753132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 23-26
Record ID
BIM-753132