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The influences of age on T lymphocyte subsets in C57BL 6 mice
Joint Authors
Xie, Jing
Wu, Huimin
Tang, Xiaochen
Cheng, Guangwen
Zhang, Jin
Liu, Jie
Li, Ping
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 1 (31 Jan. 2017), pp.108-113, 6 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The aim of this study is to evaluate the age related changes of T lymphocyte subsets in C57BL/6 mice and immune function.
Multi-color immunofluorescence techniques that were used to analyse relative numbers of T lymphocyte subsets include CD4+, CD8+, naive and memory CD4+ and CD8+, CD8+CD28+ T cells in peripheral blood of C57BL/6 mice from different age groups (Group I: 2 months old; Group II: 7 months old; Group III: 21 months old); Splenocytes isolated from different group mice were stimulated with Con A to evaluate the proliferative ability.
Compared with group I, group II had a significant reduction in the percentage of CD4+, naive CD4+ and CD8+ T cells and an increase in the percentage of CD8+ T cells, while group III had a significant reduction in the percentage of CD4+, naive CD4+ and CD8+ T cells and increase in the percentage of CD8+, memory CD4+ and CD8+ T cells in peripheral blood.
Compared with group II, group III had a significant reduction in the percentage of naive CD8+ T cells and increase in the percentage of memory CD4+ and CD8+, CD8+CD28+ T cells in peripheral blood.
The T lymphocyte proliferation in vitro showed that groups II and III had a lower proliferative capacity than group I, between groups II and III, there was not a significant difference.
We provide relative values for the T lymphocyte subsets in the different age groups of C57BL/6 mice.
The immune system began aging at 7 months old in C57BL/6 mice under a specific pathogen free environment.
American Psychological Association (APA)
Xie, Jing& Zhang, Jin& Wu, Huimin& Tang, Xiaochen& Liu, Jie& Cheng, Guangwen…[et al.]. 2017. The influences of age on T lymphocyte subsets in C57BL 6 mice. Saudi Journal of Biological Sciences،Vol. 24, no. 1, pp.108-113.
https://search.emarefa.net/detail/BIM-753702
Modern Language Association (MLA)
Xie, Jing…[et al.]. The influences of age on T lymphocyte subsets in C57BL 6 mice. Saudi Journal of Biological Sciences Vol. 24, no. 1 (Jan. 2017), pp.108-113.
https://search.emarefa.net/detail/BIM-753702
American Medical Association (AMA)
Xie, Jing& Zhang, Jin& Wu, Huimin& Tang, Xiaochen& Liu, Jie& Cheng, Guangwen…[et al.]. The influences of age on T lymphocyte subsets in C57BL 6 mice. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 1, pp.108-113.
https://search.emarefa.net/detail/BIM-753702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 112-113
Record ID
BIM-753702