Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism
Joint Authors
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Andrade, Jacqueline C.
Maria Flaviana B. Morais Braga
Guedes, Glaucia Morgana M.
Freitas, Maria A.
Quintans Júnior, Lucindo José
Tintino, Saulo R.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 1 (31 Jan. 2017), pp.59-64, 6 p.
Publisher
Publication Date
2017-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
- Physiological effects
- Vitamin K
- Antibiotics
- Antibacterial agents
- Dietary supplements
- Staphylococcus
- Biomembranes
Abstract EN
Menadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability.
Accordingly, the aim of this study was to evaluate in vitro the antibiotic-modifying activity of menadione in multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, with a gradual increase in its subinhibitory concentration.
In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action.
Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay.
Menadione, cholesterol and ergosterol showed modulatory activity at clinically relevant concentrations, characterizing them as modifiers of bacterial drug resistance, since they lowered the MIC of the antibiotics tested.
This is the first report of the antibacterial activity of menadione and its potentiation of aminoglycosides against multiresistant bacteria.
American Psychological Association (APA)
Andrade, Jacqueline C.& Maria Flaviana B. Morais Braga& Guedes, Glaucia Morgana M.& Tintino, Saulo R.& Freitas, Maria A.& Menezes, Irwin R. A.…[et al.]. 2017. Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism. Saudi Journal of Biological Sciences،Vol. 24, no. 1, pp.59-64.
https://search.emarefa.net/detail/BIM-753857
Modern Language Association (MLA)
Andrade, Jacqueline C.…[et al.]. Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism. Saudi Journal of Biological Sciences Vol. 24, no. 1 (Jan. 2017), pp.59-64.
https://search.emarefa.net/detail/BIM-753857
American Medical Association (AMA)
Andrade, Jacqueline C.& Maria Flaviana B. Morais Braga& Guedes, Glaucia Morgana M.& Tintino, Saulo R.& Freitas, Maria A.& Menezes, Irwin R. A.…[et al.]. Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 1, pp.59-64.
https://search.emarefa.net/detail/BIM-753857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 63-64
Record ID
BIM-753857