Preparation and biological evaluation of 99mTc-TMPP as a novel agent for tumor diagnosis

Abstract EN

TMPP (5, 10, 15, 20 tetrakis {4-methoxyphenyl} 21H, 23H porphyrin) was labeled with technetium-99m via direct labeling technique using stannous chloride as a reducing agent.

The optimum conditions that gave high labeling yield (95.2%) of 99mTc-TMPP complex were achieved by using 3mg TMPP, 100g SnCl2.2H2O, at pH 3 and 30min reaction time.

Accumulation of 99mTc-TMPP complex was studied in tumor bearing mice.

After intravenous injection of 99mTc-TMPP complex, tumor radioactivity uptake was high compared to normal muscle uptake and it was 7.76 folds after 30 min.

Tumor to blood ratio was 2.36 after 30 min