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Evaluation of immunostimulatory and antioxidant activities of ginger and moringa extracts against paracetamol induced hepatic damage in rats
Other Title(s)
تقييم النشاط المناعي و المضاد للأكسدة لمستخلصات الزنجبيل و المورينجا ضد العطب الكبدي المحدث بالباراسيتامول في الفئران
Joint Authors
Mahmud, Isam Abduh
Hashim, Muhammad Abd al-Azim
Abd al-Rahman, Ghadah Ibrahim
Source
Suez Canal Veterinary Medicine Journal
Issue
Vol. 20, Issue 2 (31 Dec. 2015), pp.303-316, 14 p.
Publisher
Suez Canal University Faculty of Veterinary Medicine
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The present study was conducted to investigate the ameliorative effect of both Zingiber officinale and Moringa oleifera ethanolic extracts on rats intoxicated by paracetamol through some immunological and antioxidant studies.
One hundred and eighty apparently healthy male albino rats were divided into 12 equal groups, each of 15 rats.
Gp.
(1) kept as control, Gp.
(2) was orally given paracetamol (2g/kg) for 4 weeks, Gp.
(3) was orally given ginger ethanolic extract (200 mg/kg) for 4 weeks, Gp.
(4) was orally given moringa ethanolic extract (200 mg/kg) for 4 weeks, Gp.
(5) was orally given silymarin (200 mg/kg) for 4 weeks.
Gps.
(6,7,8) (prophylaxis groups) were administered ginger, moringa ethanolic extracts or both extracts respectively for 2 weeks then paracetamol for another 2 weeks by the previous doses.
Gps.
(9, 10, 11) were firstly given paracetamol for 2 weeks then the plant extracts for the following 2 weeks.
Gp.
(12) was orally given paracetamol for 2 weeks then silymarin for the other 2 weeks.
Blood samples were collected at the end of the 2nd and 4th week of experiment.
Liver, kidney and spleen specimens were collected and immediately fixed in 10% neutral buffered formalin for histopathological examination.
The results showed lymphopenia and granulocytosis in gp.
(2) all over the experiment with increase phagocytic index only at the 2nd week in addition to increase hepatic MDA and reduction in catalase levels compared to the normal control.
The prophylactic groups (6,7,8) manifested good amelioration in the fore mentioned parameters in comparison to treatment ones (9-12).
It could be concluded that the natural plants are effective as a prophylaxis theraby against paracetamol toxicity not as a treatment ones.
Combination of plant extracts with chemical drug (paracetamol) may give a new challenge in the face of diseases.
American Psychological Association (APA)
Hashim, Muhammad Abd al-Azim& Mahmud, Isam Abduh& Abd al-Rahman, Ghadah Ibrahim. 2015. Evaluation of immunostimulatory and antioxidant activities of ginger and moringa extracts against paracetamol induced hepatic damage in rats. Suez Canal Veterinary Medicine Journal،Vol. 20, no. 2, pp.303-316.
https://search.emarefa.net/detail/BIM-754172
Modern Language Association (MLA)
Hashim, Muhammad Abd al-Azim…[et al.]. Evaluation of immunostimulatory and antioxidant activities of ginger and moringa extracts against paracetamol induced hepatic damage in rats. Suez Canal Veterinary Medicine Journal Vol. 20, no. 2 (2015), pp.303-316.
https://search.emarefa.net/detail/BIM-754172
American Medical Association (AMA)
Hashim, Muhammad Abd al-Azim& Mahmud, Isam Abduh& Abd al-Rahman, Ghadah Ibrahim. Evaluation of immunostimulatory and antioxidant activities of ginger and moringa extracts against paracetamol induced hepatic damage in rats. Suez Canal Veterinary Medicine Journal. 2015. Vol. 20, no. 2, pp.303-316.
https://search.emarefa.net/detail/BIM-754172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 313-315
Record ID
BIM-754172