Biochemical and Histopathological study on the effect of nigella sativa and curcumin on Aflatoxin residues in quails

Abstract EN

Current study investigated the effects of Nigella sativa (NS) and Curcumin on Aflatoxins (AFs) residues on some hepatic and renal functions in quails.

A total 120 unsexed Japanese quails chicks one-week-old were equally divided for one month of experiment into 4 groups; G1, G2, G3 and G4.

G1; was considered control group and was given AFs free diet, G2; was given 2.5 mg/kg diet AFs, G3; was given AFs 2.5 mg/kg diet and 1.5% NS and G4, was given 2.5 mg/kg diet AFs with Curcumin 400 mg/kg diet, respectively.

Total cholesterol (TC), triacylglycerol (TG), high density lipoprotein- cholesterol (HDL-c), low density lipoprotein- cholesterol (LDL-c), creatinine, uric acid, and Aflatoxin residues were determined.

Also the histopathological examinationon liver was performed.

TC, TG and LDL-c were significantly (P≤0.5) increased in G2 than G1, while reduced in G3 and G4 than G2.

However, HDL-c was significance (P≤0.05) decrease in G2 than G1.

While, increased in G3 and G4 than G2.

Creatinine and uric acid were significantly (P≤0.5) elevated in G2 than G1, while it was significantly (P≤0.5) decreased in G3 and G4 than G2.

AFs residues in liver tissue was significantly (P≤0.05) elevated in G2 than G1 and significantly (P≤0.05) reduced in G3 and G4 than G2.

This study indicated that Addition of NS and Curcumin to quails diets; improved via modulating lipid profile, creatinine, uric acid and reduction of AFs residues with respect to hepatic and renal function