دراسة مرضية وقائية لتأثير المستخلصات لنبات المرير Sonchus oleraceus على خلايا سرطان الغدة اللبنية in vivo في الفئران

Abstract EN

This study was designed to evaluate the prophylactic and pathological effect of the ethanolic (EE), cold aqueous (CAE), and hot aqueous (HAE) extracts of the Sonchus oleraceus on cancer cells growth of mammary adenocarcinoma as in vivo.

The in vivo study was performed to evaluate the effect of the three types of the extracts.

The LD50 was (5 g/kg, 6 g/kg and 8 g/kg) for ethanolic, hot aqueous and cold aqueous extracts respectively.

The mice groups were given doses of the three extracts at period of two weeks, and were treated for two weeks after that the groups of mice were transplanted with the cancer cells.

The histopathological study revealed pathological changes in tumor mass, and noticed necrosis in most of the cancer cells in the group that treated wiyh ethanolic extract.

The histopathological results showed that the extracts of Sonchus oleraceus were induced necrosis in the cancer cells and also caused few necrotic changes in the normal tissue in the in vivo study