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Inflammatory stress and idiosyncratic drugs hepatotoxicity in rabbit
Other Title(s)
الجهد الالتهابي و الأعراض غير المتوقعة للأدوية على سمية الكبد-في الأرانب
Author
al-Khuzai, Hasan Tumah Muhammad
Source
al-Qadisiyah Journal of Veterinary Medicine Sciences
Issue
Vol. 12, Issue 2 (31 Dec. 2013), pp.7-12, 6 p.
Publisher
al-Qadisiyah University College of Veterinary Medicine
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Back ground: idiosyncratic drug hepatotoxicity is none or time related, unpredictable, occurs infrequently and can be fatal.
It was proposed that inflammatory or oxidative stress occurs randomly in patients even after asymptomatic incidence can precipitate drug hepatotoxicity.
Aim: To measure hepatotoxicity of diclofenac in rabbit serum following the incidence of inflammatory stress by lipopolysaccharide (LPS) and correlate this to various stress parameters as Malondialdehyed (MDA).
Method: 24 rabbits were divided into four groups (6 each) according to type of treatment.
Group 1: control (received normal saline).
Group 2 received diclofenac sod.
(5mg/kg, orally 3times daily for three days).
Group 3: received lipopolysaccharide (150µg/kg, i.v, 24 hours before killing.
Group 4: received diclofenac sod.
+ Lipopolysaccharide (5mg/kg orally + 150µg/kg, i.v 24 hours before killing).
Then for each animal were measure, liver M D A, liver enzymes.
Conclusion: LPS potentiated the hepatotoxic effect of diclofenac sod.
The effect is mediated by oxidative and inflammatory reactions as demonstrated by increase in liver tissue M D A.
American Psychological Association (APA)
al-Khuzai, Hasan Tumah Muhammad. 2013. Inflammatory stress and idiosyncratic drugs hepatotoxicity in rabbit. al-Qadisiyah Journal of Veterinary Medicine Sciences،Vol. 12, no. 2, pp.7-12.
https://search.emarefa.net/detail/BIM-755205
Modern Language Association (MLA)
al-Khuzai, Hasan Tumah Muhammad. Inflammatory stress and idiosyncratic drugs hepatotoxicity in rabbit. al-Qadisiyah Journal of Veterinary Medicine Sciences Vol. 12, no. 2 (2013), pp.7-12.
https://search.emarefa.net/detail/BIM-755205
American Medical Association (AMA)
al-Khuzai, Hasan Tumah Muhammad. Inflammatory stress and idiosyncratic drugs hepatotoxicity in rabbit. al-Qadisiyah Journal of Veterinary Medicine Sciences. 2013. Vol. 12, no. 2, pp.7-12.
https://search.emarefa.net/detail/BIM-755205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 11-12
Record ID
BIM-755205