Nitric oxide donor dilates aorta in salt loaded rats via activation of inward-rectifier potassium channels
Joint Authors
Shaykhah, Mazhar S.
Salihi, Abbas B. Q.
Mahmud, Almas M. R.
al-Habib, Umar Abd al-Majid
Mawlud, Ismail Mustafa
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 28, Issue 5 (31 Oct. 2016), pp.69-77, 9 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2016-10-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Since the mechanism of salt impairing NO-induced vascular relaxation is not fully clear, this study was designed to investigate the role of potassium (K+) channels in the vasodilatory effects of NO donor in salt loaded rats.
Isolated thoracic aortic rings of adult male albino rats fed 8% NaCl containing diet for six weeks were used for isometric tension recording using PowerLab tissue bath system.
The recorded data revealed that high salt diet (HS) did not change the relaxation responses to sodium nitroprusside (SNP, an NO donor) in rat's thoracic aortic rings.
SNP-induced relaxation in salt loaded rats was significantly lower in rings contracted by high K+ than phenylephrine (PE, a selective α1-adrenergic receptor agonist).
On the other hand, incubation of aortic rings from salt loaded rats with inward-rectifier K+ (KIR) channel blockers either individually or simultaneously with other K+ channel blockers significantly inhibited SNP-induced relaxation in PE-contracted rings; however incubation of rings with either calcium (Ca+2)-activated K+ (KCa), ATP-dependent (KATP) or voltage-sensitive K+ (KV) channels blockers had non-significant effects on relaxation responses of SNP.
These results reveal that NO donor-induced aortic relaxation from salt loaded rats is mainly mediated by the activation of KIR channels
American Psychological Association (APA)
Salihi, Abbas B. Q.& Shaykhah, Mazhar S.& Mawlud, Ismail Mustafa& Mahmud, Almas M. R.& al-Habib, Umar Abd al-Majid. 2016. Nitric oxide donor dilates aorta in salt loaded rats via activation of inward-rectifier potassium channels. ZANCO Journal of Pure and Applied Sciences،Vol. 28, no. 5, pp.69-77.
https://search.emarefa.net/detail/BIM-756696
Modern Language Association (MLA)
Salihi, Abbas B. Q.…[et al.]. Nitric oxide donor dilates aorta in salt loaded rats via activation of inward-rectifier potassium channels. ZANCO Journal of Pure and Applied Sciences Vol. 28, no. 5 (2016), pp.69-77.
https://search.emarefa.net/detail/BIM-756696
American Medical Association (AMA)
Salihi, Abbas B. Q.& Shaykhah, Mazhar S.& Mawlud, Ismail Mustafa& Mahmud, Almas M. R.& al-Habib, Umar Abd al-Majid. Nitric oxide donor dilates aorta in salt loaded rats via activation of inward-rectifier potassium channels. ZANCO Journal of Pure and Applied Sciences. 2016. Vol. 28, no. 5, pp.69-77.
https://search.emarefa.net/detail/BIM-756696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 75-77
Record ID
BIM-756696