Histological interfaces of liver, kidney and cerebrum in male rats exposed to fluoxetine

Joint Authors

Hamad, Sarkawt H.
Hasan, Dlshad Husayn
Mahmud, Nizar Muhammad Sharif
Rasul, Khidr H.

Source

ZANCO Journal of Pure and Applied Sciences

Issue

Vol. 28, Issue 5 (31 Oct. 2016), pp.126-135, 10 p.

Publisher

Salahaddin University-Erbil Department of Scientific Publications

Publication Date

2016-10-31

Country of Publication

Iraq

No. of Pages

10

Main Subjects

Natural & Life Sciences (Multidisciplinary)

Abstract EN

Fluoxetine is an antidepressant of selective serotonin reuptake inhibitor drug.

It is used in treatment of depression, panic and anxiety.

Also, it may decrease the risk of suicide in those over the age of sixty-five years.

The current study was planned to investigate the histological effect of oral administration of fluoxetine (10 mg/kg body weight/day) on liver, kidney and cerebrum of male rats.

Rats were divided randomly and equally into two groups; control group (n=8) and fluoxetine-treated group (n=8).

After one month of administration; liver, kidney and cerebrum tissues would be taken to make histological slides.

Histological alterations were observed in liver such as presence of few dead hepatocytes, congested blood vessels and inflammatory cells.

Kidney also showed histological changes; in the cortex region include shrunken glomeruli tuft, hemorrhage and degenerated cells while in the medullary region included thickened wall of tubules and some of the epithelial tubule cells were degenerated.

Alterations in the cerebrum were the presence of dead neuronal cells in the second and third layers of grey matter were due to fluoxetine.

In conclusion, fluoxetine had a minute effect on the histological structure of liver, kidney and cerebrum tissues

American Psychological Association (APA)

Hamad, Sarkawt H.& Hasan, Dlshad Husayn& Rasul, Khidr H.& Mahmud, Nizar Muhammad Sharif. 2016. Histological interfaces of liver, kidney and cerebrum in male rats exposed to fluoxetine. ZANCO Journal of Pure and Applied Sciences،Vol. 28, no. 5, pp.126-135.
https://search.emarefa.net/detail/BIM-756717

Modern Language Association (MLA)

Rasul, Khidr H.…[et al.]. Histological interfaces of liver, kidney and cerebrum in male rats exposed to fluoxetine. ZANCO Journal of Pure and Applied Sciences Vol. 28, no. 5 (2016), pp.126-135.
https://search.emarefa.net/detail/BIM-756717

American Medical Association (AMA)

Hamad, Sarkawt H.& Hasan, Dlshad Husayn& Rasul, Khidr H.& Mahmud, Nizar Muhammad Sharif. Histological interfaces of liver, kidney and cerebrum in male rats exposed to fluoxetine. ZANCO Journal of Pure and Applied Sciences. 2016. Vol. 28, no. 5, pp.126-135.
https://search.emarefa.net/detail/BIM-756717

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 153

Record ID

BIM-756717