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Synthesis and bioactivities of 1-aryl-4-hydroxy-1H-pyrrol-2 (5H)-one derivatives bearing 1, 3, 4-oxadiazole moiety
Joint Authors
Yang, Song
Zhou, Jian
Fang, He Shu
Wu, Zhi Bing
Song, Bao An
Chen, Ling
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 3 (31 Mar. 2017), pp.315-323, 9 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
In this paper, a variety of 1-aryl-4-hydroxy-1H-pyrrol-2(5H)-one derivatives bearing 1,3,4-oxadiazole moiety were designed and synthesized.
Preliminary bioassays suggested that these compounds not only exhibited favorable antibacterial activity toward plant pathogenic bacteria including Xanthomonas oryzae pv.
oryzae (Xoo), Ralstonia solanacearum (R.
solanacearum), and Xanthomonas axonopodis pv.
citri.
(Xac), but also demonstrated certain curative and protective activities against Tobacco mosaic virus (TMV).
Further studies revealed that compounds 8a and 8l exerted the best inhibition effect against Xoo with the half-maximal effective concentration (EC50) values of 8.6 and 7.3 lg/mL, respectively, which were better than that of commercial agricultural antibacterial bismerthiazol (EC50 =92.6 lg/mL).
Given the above results, this kind of compounds can be further studied and explored as alternative antibacterial agents.
American Psychological Association (APA)
Wang, Pei-Yi& Chen, Ling& Zhou, Jian& Fang, He Shu& Wu, Zhi Bing& Song, Bao An…[et al.]. 2017. Synthesis and bioactivities of 1-aryl-4-hydroxy-1H-pyrrol-2 (5H)-one derivatives bearing 1, 3, 4-oxadiazole moiety. Journal of Saudi Chemical Society،Vol. 21, no. 3, pp.315-323.
https://search.emarefa.net/detail/BIM-756931
Modern Language Association (MLA)
Wang, Pei-Yi…[et al.]. Synthesis and bioactivities of 1-aryl-4-hydroxy-1H-pyrrol-2 (5H)-one derivatives bearing 1, 3, 4-oxadiazole moiety. Journal of Saudi Chemical Society Vol. 21, no. 3 (Mar. 2017), pp.315-323.
https://search.emarefa.net/detail/BIM-756931
American Medical Association (AMA)
Wang, Pei-Yi& Chen, Ling& Zhou, Jian& Fang, He Shu& Wu, Zhi Bing& Song, Bao An…[et al.]. Synthesis and bioactivities of 1-aryl-4-hydroxy-1H-pyrrol-2 (5H)-one derivatives bearing 1, 3, 4-oxadiazole moiety. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 3, pp.315-323.
https://search.emarefa.net/detail/BIM-756931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 322-323
Record ID
BIM-756931