Synthesis and antimicrobial studies of furyl based new bispyrazolines linked via aliphatic chains
Joint Authors
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 3 (31 Mar. 2017), pp.251-261, 11 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
The symmetrical bisheterocycles built around varying lengths aliphatic linkers have been synthesized from the easy cyclization reactions of bischalcones with phenyl hydrazine by refluxing in dry EtOH and glacial acetic acid medium.
The intermediates in turn were prepared in the good yields from O-alkylation of hydroxy substituted chalcone with suitable 1,x-dibromoalkanes in the presence of anhydrous K2CO3, dry acetone and Bu4N+I as PTC.
The chalcone was obtained from the Claisen–Schmidt condensation reaction of p-hydroxyacetophenone with 2-furfuraldehyde.
The structures of bischalcones and bispyrazolines were fully characterized by using various spectroscopic techniques including IR, 1H NMR, 13C NMR & Mass (ESI) and purity of these products were confirmed from their elemental analysis results.
The newly prepared compounds were also screened for their antimicrobial activities against seven bacterial and five fungal strains by using serial tube dilution method.
Some of the compounds exhibited significant activities against the tested microorganisms
American Psychological Association (APA)
Yusuf, Muhammad& Solanki, Indu. 2017. Synthesis and antimicrobial studies of furyl based new bispyrazolines linked via aliphatic chains. Journal of Saudi Chemical Society،Vol. 21, no. 3, pp.251-261.
https://search.emarefa.net/detail/BIM-757197
Modern Language Association (MLA)
Yusuf, Muhammad& Solanki, Indu. Synthesis and antimicrobial studies of furyl based new bispyrazolines linked via aliphatic chains. Journal of Saudi Chemical Society Vol. 21, no. 3 (Mar. 2017), pp.251-261.
https://search.emarefa.net/detail/BIM-757197
American Medical Association (AMA)
Yusuf, Muhammad& Solanki, Indu. Synthesis and antimicrobial studies of furyl based new bispyrazolines linked via aliphatic chains. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 3, pp.251-261.
https://search.emarefa.net/detail/BIM-757197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 260-261
Record ID
BIM-757197