Synthesis, characterization and DNA cleavage studies of isomeric pyridyl-tetrazole ligands and their Ni (II) and Zn (II) complexes
Joint Authors
Krishna, V.
Babu, M. S. Surendra
Umamaheswara Rao, B.
Mustafa, Shaik
Rao, Nageswara
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 3 (31 Mar. 2017), pp.291-299, 9 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
A new series of Ni(II) and Zn(II) complexes were synthesized from bidentate isomeric pyridyl tetrazole ligands such as 2-(1-vinyl-1H-tetrazol-5-yl)pyridine (L1), N,N-dimethyl-3-(5-(pyri din-2-yl)-1H-tetrazol-1-yl)propan-1-amine(L2), 2-(2-vinyl-2H-tetrazol-5-yl)pyridine(L3), N,N-dime thyl-3-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)propan-1-amine (L4).
All the complexes were characterized by the elemental analysis, molar conductance, FTIR, UV–vis and magnetic studies.
The conductance and spectroscopic data suggested that, the ligands act as monobasic bidentate ligands and form octahedral complexes with general formula [M(L14)2Cl2], (M = Ni(II) and Zn(II)).
In addition metal complexes displayed good antioxidant and moderate nematicidal activities.
The cytotoxicity of ligands and their metal complexes have been evaluated by MTT assay.
The DNA cleavage activity of the metal complexes was performed using agarose gel electrophoresis in the presence and absence of oxidant H2O2.
All metal complexes showed significant nuclease activity in the presence of H2O2.
American Psychological Association (APA)
Babu, M. S. Surendra& Umamaheswara Rao, B.& Krishna, V.& Mustafa, Shaik& Rao, Nageswara. 2017. Synthesis, characterization and DNA cleavage studies of isomeric pyridyl-tetrazole ligands and their Ni (II) and Zn (II) complexes. Journal of Saudi Chemical Society،Vol. 21, no. 3, pp.291-299.
https://search.emarefa.net/detail/BIM-757206
Modern Language Association (MLA)
Babu, M. S. Surendra…[et al.]. Synthesis, characterization and DNA cleavage studies of isomeric pyridyl-tetrazole ligands and their Ni (II) and Zn (II) complexes. Journal of Saudi Chemical Society Vol. 21, no. 3 (Mar. 2017), pp.291-299.
https://search.emarefa.net/detail/BIM-757206
American Medical Association (AMA)
Babu, M. S. Surendra& Umamaheswara Rao, B.& Krishna, V.& Mustafa, Shaik& Rao, Nageswara. Synthesis, characterization and DNA cleavage studies of isomeric pyridyl-tetrazole ligands and their Ni (II) and Zn (II) complexes. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 3, pp.291-299.
https://search.emarefa.net/detail/BIM-757206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 298-299
Record ID
BIM-757206