Early biochemical markers of hypoxic ischemic encephalopathy in neonates

Abstract EN

Objectives: The aim of this study is to evaluate some biochemical parameters including serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) in newborns with birth asphyxia.

Methods: This retrospective study was conducted in King Hussein medical center over two year period.

Fifty seven patients were enrolled in this study who fulfills the inclusion criteria (group A), another sixty patients were enrolled as control (group B).

Biochemical parameters as CPK and LDH were measured in both groups.

Results: Forty seven patients out of fifty (82%) showed liver involvement indicated by the elevation of LDH and CPK, done in the first three days of life.

Most of the patients were in the grade one of HIE according to sarnat and sarnat classification.

Statistical analysis was done for the available data and showed significant elevation of both CPK and LDH in asphyxiated babies.

Conclusion: Measurement of both CPK and LDH in babies with high risk and who are suspected to have birth asphyxia, can help in predicting those who are candidate for neuroprotective measures as hypothermia, which might lead to significant improvement In neurodevelopment abilities of neonate later on.