The association between lympho vascular invasion and other prognostic indicators in operable breast cancer : experience at King Hussein Medical center

Abstract EN

Objective: To evaluate the association between lymphovascular invasion (LVI) and different clinicopathologic features of invasive breast cancer.

Methods: Clinicopathologic and demographic data from a cohort of 298 patients, who were referred to surgery clinics at King Hussein Medical Center (KHMC) between 2007 and 2014, were retrieved and analyzed.

Results: The average age of the cohort under investigation was 51.2 years with most of the patients having invasive breast carcinoma.

Lymphovascular invasion was detected in 53% of the patients.

Patients with lymphovascular invasion were more likely to have larger tumors (4.2 vs.

3.3cm p=0.02).

Additionally, they were more likely to have progesterone negative (p=0.032), and Her2 positive tumors (p=0.003).

Patients with negative Lymphovascular were more likely to have negative perineural invasion (p=0.0001).

Conclusion: Lymphovascular invasion was associated with larger tumors, Progesterone negativity and Her-2 positivity.

Lymphovascular invasion should be incorporated in tumor classification and treatment modality selection.