Chromosomal and hormonal abnormalities in azoospermic patients in a military Jordanian cohort

Abstract EN

Objective: To report the prevalence of chromosomal abnormalities and hormonal profile in azoospermic males referred to endocrine clinic from IVF center and urology clinic at King Hussein Medical Center.

Methods: Out of 1100 infertile males; thirty patients with azoospermia were subjected for chromosomal studies.

Results: Chromosomal abnormalities were found in 7/30 patients that constitute 23% of azoospermic group and 0.6% of the total group and almost 86% of them were Kline felter's syndrome.

Hormonal profile showed a significantly higher FSH, LH and lower serum testosterone in those with chromosomal alterations versus those with azoospermia without chromosomal abnormalities.

Conclusion: The prevalence of chromosomal abnormalities is high in azoospermic patients and warrant routine chromosomal investigations