Family history of glaucoma and disease severity
Joint Authors
Li, Xilong
Adams Huet, Beverley
Vu, Khiem T.
Markel, Nathan L.
Parikh, Kisan
al-Budur, Muhannad Q.
Kooner, Karanjit S.
Source
Journal of the Royal Medical Services
Issue
Vol. 23, Issue 4 (31 Dec. 2016), pp.36-40, 5 p.
Publisher
The Royal Medical Services Jordan Armed Forces
Publication Date
2016-12-31
Country of Publication
Jordan
No. of Pages
5
Main Subjects
Abstract EN
Objectives: To determine if a positive family history of glaucoma, overtime, translates to a more severe form of the disease.
Methods: A retrospective chart review of 359 consecutive patients diagnosed with primary open-angle glaucoma (POAG) and normal tension glaucoma was performed.
Family history of glaucoma, age, gender, race, cup/disk (C/D) ratio, visual field (VF) defects, intraocular pressure (IOP), central corneal thickness (CCT), and current glaucoma medications were recorded.
Characteristics of patients with positive family history (Group A) and negative family history(Group B) were compared using Fisher’s Exact and Wilcoxon Rank sum tests for categorical and continuous variables, respectively.
Results: There were 144 (40.1%) patients in Group A and 215 (59.9%) patients in Group B.
Racially, both groups were similar, p= 0.44.
Patients in Group A were younger at diagnosis, (61.9 ± 13.5 years vs 65.2 ± 12.5; p=0.02), had greater percentage of females (50.7% vs 37.7%; p= 0.02), had thicker CCT, μm, (546 ± 58.1 vs 532.7 ± 40.2; p=0.02), higher IOP (16.6 ± 3.9 vs 1.6 ± 3.9; p= 0.02), advanced (C/D ≥ 0.9) cupping (32.2% vs 22.4%; p=0.05) and higher prevalence of moderate to severe VF defects (66.2% vs 54.8%, p= 0.04), compared with normal to mild VF defects.
Conclusion: Our study has suggested that a positive family history of glaucoma may be associated with higher IOP, as well as greater prevalence of advanced cupping and moderate to severe VF defects.
Vigilance and aggressive treatment are warranted for these patients.
American Psychological Association (APA)
al-Budur, Muhannad Q.& Vu, Khiem T.& Markel, Nathan L.& Parikh, Kisan& Li, Xilong& Adams Huet, Beverley…[et al.]. 2016. Family history of glaucoma and disease severity. Journal of the Royal Medical Services،Vol. 23, no. 4, pp.36-40.
https://search.emarefa.net/detail/BIM-758490
Modern Language Association (MLA)
al-Budur, Muhannad Q.…[et al.]. Family history of glaucoma and disease severity. Journal of the Royal Medical Services Vol. 23, no. 4 (Dec. 2016), pp.36-40.
https://search.emarefa.net/detail/BIM-758490
American Medical Association (AMA)
al-Budur, Muhannad Q.& Vu, Khiem T.& Markel, Nathan L.& Parikh, Kisan& Li, Xilong& Adams Huet, Beverley…[et al.]. Family history of glaucoma and disease severity. Journal of the Royal Medical Services. 2016. Vol. 23, no. 4, pp.36-40.
https://search.emarefa.net/detail/BIM-758490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40
Record ID
BIM-758490