Protective and curative effects of panax ginseng aqueous crude extract on biochemical changes of BALB c mice exposed to aflatoxins

Abstract EN

The current study was designed to investigate the protective and curative effects of Panax ginseng aqueous crude extract (PACE) against the changing of liver enzymes and some renal functions, induced by aflatoxins exposure in vivo.

Aflatoxins (AFs) increased significantly (P ≤ 0.05) the levels of Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Blood Urea, Serum Uric Acid and Serum Creatinine in mice orally administrated with 9 mg/kg b.

w crude extraction of AFs.

Whereas the levels of Bilirubin showed different values in all groups ranging from 0.29 mg/dl to 0.45 mg/dl which were in normal range (0.17-1 mg/dl).

The mice were pretreated with 150, 100, and 50 mg/kg b.

w doses of PACE orally for ten consecutive days, led to significant reductions in levels of the parameters which were studied (100 mg/kg b.

w was near to the normal values in a significant manner, whereas 50mg/kg b.

w was appeared non- significant result (p ≥ 0.05) with uric acid).

Furthermore, post-treated mice with same doses of PACE orally for twenty one consecutive days revealed a significant result at 150 mg/kg b.

w more than 100 mg/kg b.

w, however the third concentration gave non-significant results (p ≥ 0.05).-