Preparation and characterization of nano titanium molybdate gel as a base material for 99Mo 99mTc chromatographic column generator

Abstract EN

Nano crystalline porous titanium molybdate-99Mo (Ti99Mo) gel was prepared by dropwise addition of molybdate (VI)-99 The Egyptian Society of Nuclear Sciences and Applications Mo solution to a vigorously stirred mixture of TiCl3 and (NH4)2 Ce(NO3)6 solution at pH 5.

The precipitated gel was dried at 50°C.

The performance of the prepared 99Mo/99mTc column generator based on the optimumTi99Mo gel was investigated.

It was found that the specifications of the 99mTc elutates met the requirements of use in nuclear medicine applications (99mTc elution yield = 88 %, 99Mo breakthrough = 5 × 10-3 %, eluate pH = 6-6.5, radiochemical purity = 98.2 % and accepted chemical purity).

TiMo gel was characterized by BET surface area and pore size analyzer, DLS, XRD, SEM, IR spectroscopy and thermal analysis (TGA and DTA).

The optimum TiMo gel was found to be crystalline in the form of brownish yellow fine granules with a particle size average of 58.1 nm and a total pore volume of 4.1 x 10-2 cm3/g.