Effect of salvia aegyptiaca aqueous extract on some neurohormonal disorders induced by carbon tetrachloride in adult male albino rats

Abstract EN

Daily intraperitoneal injection of carbon tetrachloride (CCl4) at a dose level of 1.0 ml/kg body weight caused a gradual and significant decrease in tyrosine amino acid.

As a result of this injection, dopamine (DA) and norepinephrine (NE) monoamines were decreased in different brain areas under investigation (cerebellum, pons & medulla oblongata, striatum, cerebral cortex, hypothalamus, midbrain, and hippocampus) where, CCl4 injection decreased serum luteinizing hormone (LH) and testosterone.

Animals that received a daily oral administration of Salvia aegyptiac aqueous extract at a dose equivalent to 2.0g/kg body weight, slightly increased brain contents of tyrosine, dopamine and norepinephrine.

Moreover a significant increase was observed in LH and testosterone from the first day till the end of the experiential period.

However, animals that were pretreated with a daily oral administration of Salvia aegeptiaca extract at a dose level equivalent to 2.0 g/kg body weight one hour before being intraperitoneally injected with CCl4, showed a significant increase in DA, NE, and tyrosine as compared to those treated with CCl4 alone; and thus Salvia extract may be attenuate CCl4 effect through experimental period